Epilepsy Behav. 2025 Oct 9;173:110755. doi: 10.1016/j.yebeh.2025.110755. Online ahead of print.
ABSTRACT
Depression commonly co-occurs in people with epilepsy (PWE). Reducing depression in PWE may contribute to improved quality of life and outcomes. Project UPLIFT, a distance-delivered, mindfulness-based cognitive therapy program has reduced depressive symptoms among PWE. Little is known about the acceptability of the program among African Americans with epilepsy. Thus, we conducted a formative evaluation to assess African Americans’ cultural adaptation needs and to identify any associated required changes.
METHODS: Focus groups of African Americans with epilepsy and support persons to African Americans with epilepsy were conducted to elicit suggestions for program adaptation. Participants received the intervention materials prior to the focus group. Using a semi-structured guide, we asked about their perceptions of Project UPLIFT. The focus groups were recorded and transcribed. We used thematic analysis to explore acceptability of Project UPLIFT for African Americans with epilepsy.
RESULTS: There were 6 focus groups with 4 of PWE (n = 22) and 2 of support persons (n = 13). Participants affirmed the acceptability and perceived effectiveness of Project UPLIFT. With affirming acceptability, they liked aspects of the program and suggested minimal changes. Participants were willing to try the activities and identified the content as true to their experience. With perceived effectiveness, they described variations in experiences and highlighted the value of group-based delivery.
CONCLUSIONS: Project UPLIFT, as presented in previous trials, appears acceptable, and of interest, to African Americans with epilepsy. These results support testing the efficacy of this intervention in reducing depression among African Americans with epilepsy.
PMID:41072060 | DOI:10.1016/j.yebeh.2025.110755
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