Mendelian Randomization Analysis Reveals Causal Associations Between Beverages and Irritable Bowel Syndrome: Alcohol, but Not Others

Food Sci Nutr. 2025 Jul 31;13(8):e70761. doi: 10.1002/fsn3.70761. eCollection 2025 Aug.

ABSTRACT

Observational studies have suggested that beverage intake could have potential connections with irritable bowel syndrome (IBS). However, the association patterns and the underlying mechanisms remain unknown. The study identified potential causal relationships between alcohol intake and IBS, showing positive associations for alcohol intake frequency (odds ratio = 1.18, 95% confidence interval = 1.09-1.26; p < 0.001). Psychiatric disorders were found to play mediative roles with mediation effects of 25.22%, 45.77%, and 12.10% for depression (broad), major depression disease, and attention deficit hyperactivity disorder, respectively. These findings suggest that reducing alcohol intake may help prevent IBS, especially in individuals with psychiatric conditions.

PMID:40755502 | PMC:PMC12313541 | DOI:10.1002/fsn3.70761