The longitudinal bidirectional association between cardiovascular disease and depressive symptoms among middle-aged and elderly adults: evidence from a nationwide cohort study in China

Front Psychiatry. 2025 Jul 2;16:1559092. doi: 10.3389/fpsyt.2025.1559092. eCollection 2025. ABSTRACT BACKGROUND: Although cardiovascular disease (CVD) and depressive symptoms frequently co-occur, their temporal directional relationship remains poorly understood. This...

Continuous-flow synthesis of 1,4,6,7-tetrahydro-5H-[1,2,3]triazolo[4,5-c]pyridines towards key intermediates of clinical candidates JNJ-54175446 and zanvipixant (JNJ-55308942) with antidepressant activity

RSC Adv. 2025 Jul 16;15(31):25202-25208. doi: 10.1039/d5ra03780h. eCollection 2025 Jul 15. ABSTRACT 1,4,6,7-Tetrahydro-5H-[1,2,3]triazolo[4,5-c]pyridines are potent antagonists of the P2X7 receptor, a key regulator of neuroinflammation associated with depression. Two...