The Association Between Hearing Impairment and Incident Depression in Older Adults: A Longitudinal Analysis

J Gerontol A Biol Sci Med Sci. 2025 Nov 7:glaf250. doi: 10.1093/gerona/glaf250. Online ahead of print.

ABSTRACT

BACKGROUND: Hearing loss (HL) is common in older adults and is associated with several adverse health outcomes. Although previous research has demonstrated a link between hearing impairment and depression, most studies have been cross-sectional or relied on a single baseline measure of hearing.

AIMS: To investigate the association between longitudinal, time-varying audiometric measures of hearing and incident depression in older adults. A secondary aim was to assess whether hearing aid use modifies this association over time in those with moderate to severe HL.

METHODS: We included 1,260 participants who underwent pure-tone audiometry at baseline, 18 months, and 36 months. Depression was defined using the CES-D-10 scale, with a cut-score of ≥ 8. Cox proportional hazards analyses were used to examine the link between hearing status (normal, mild HL, moderate/severe HL) and depression, adjusted for demographic, lifestyle, and clinical variables.

RESULTS: Over a median follow-up of 7.3 years, participants with moderate to severe HL had a higher risk of incident depression (adjusted HR [aHR] 1.24; 95% CI 1.08-1.43, p < 0.01) compared with participants with normal hearing. Hearing aid use (≥ 6 hours self-reported use per day on average) in those with moderate to severe HL was associated with significantly reduced risk of incident depression (aHR 0.65; 95% CI 0.49-0.87, p < 0.01).

CONCLUSION: Moderate to severe HL is a significant risk factor for incident depression among older adults. Hearing aid use attenuated this risk. Future research should investigate mechanistic pathways linking HL and mood disturbances.

PMID:41206658 | DOI:10.1093/gerona/glaf250