Anxiety is a severe social problem. It is a disease entity that occurs alone or accompanies other diseases such as depression, phobia, or post-traumatic stress disorder. Our earlier studies demonstrated that blockage of arachidonic acid (AA) pathway via inhibition of cyclooxygenase-2 (COX-2) enzyme can modulate mGluRs-induced anxiety-like behavior. Here, we hypothesized that modulation of 2-arachidoglycerol (2-AG), a component of the AA pathway, concomitantly with modulation of mGluR7 signaling,...

With the advent of human neuroimaging, researchers were drawn to the idea that by better understanding the human brain, more effective mental health interventions could be developed. It has been more than 20 years since the first functional magnetic resonance imaging (fMRI) studies were conducted to examine changes in brain activation with anxiety-related treatments and more than 60 studies have since been published in this vein. For the current review, we conduct a systematic review of this...

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The objective of this perspective article is to explore the creation of a new syndrome specific to the Canadian city of Montreal: Conophobia. In a more academic way, the aim is to think about the process which leads to the creation of a new clinical entity and to question how the name of a disease is chosen. In the literature, it is illustrated by syndromes with a name of a city: Stockholm syndrome, Stendhal syndrome, Pisa syndrome, Havana syndrome, Paris syndrome, Lima syndrome or Copenhagen...