Transthyretin amyloidosis is a rare disorder caused by the accumulation of misfolded transthyretin amyloid in organs. The symptoms can include neuropathy, cardiomyopathy, nephropathy, depression and cognitive decline. Because of the non-specificity of symptoms, it usually takes considerable time to diagnose, which delays specific therapy and leads to a worse prognosis. Our case highlights the psychological symptoms of this disorder that initially delayed diagnosis, and later helped to reach the...

CONCLUSIONS: People with AIH had impaired HRQoL compared with controls, particularly in terms of physical well-being. HRQoL scores are associated with symptom burden, encompassing both somatic and psychosocial dimensions.

CONCLUSIONS: LC significantly impacts mental health, particularly through increased anxiety, depression, and somatoform symptoms, especially in patients with severe LC physical symptoms. Psychological interventions targeting distinct symptom clusters may improve both mental and physical outcomes. Early mental health screening and tailored interventions are recommended for LC assessment and treatment.

CONCLUSION: Network analysis reveals the multidimensional and reciprocal nature of long-term TBI symptoms. Attention deficits bridge cognitive and psycho-emotional areas, whereas psycho-emotional symptoms influence self-perceived performance. Self-reported cognitive impairments should be emphasized in therapy as they are linked rather to sleep, visual disturbances, and anxiety than to objective deficits. Network analysis is valuable for understanding TBI symptom complexity and exploring...