Sleep-Related Hypoventilations

Resources for Patients and Caregivers

Sleep-related hypoventilation describes breathing that is too slow or shallow during sleep. The first signs of hypoventilation typically occur during sleep because when we’re awake, our brain can play a more active role5 in regulating our breathing.


Cluster Number:
Wiki Number: 42-Sleep-Related Hypoventilations
US Patients:
World Patients:
Sex Ratio: 
Age Onset: 
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Resources for Physicians, Counselors and Researchers


The world-wide medical research
reports chosen for each diagnosis 

Clicking each title opens the
PubMed article’s summary-abstract.

  • The effect of brain serotonin deficiency on breathing is magnified by age
    by Huy Pho on May 18, 2022

    Serotonin is an important mediator modulating behavior, metabolism, sleep, control of breathing, and upper airway function, but the role of aging in serotonin-mediated effects has not been previously defined. Our study aimed to examine the effect of brain serotonin deficiency on breathing during sleep and metabolism in younger and older mice. We measured breathing during sleep, hypercapnic ventilatory response (HCVR), CO(2) production (VCO(2) ), and O(2) consumption (VO(2) ) in 16-18-week old...

  • Recognizing New-Onset Sleep Disorders in Autoimmune Encephalitis Often Prompt Earlier Diagnosis
    by Frank Ralls on March 3, 2022

    Sleep/wake disorders are common in patients with autoimmune encephalitis, sometimes the most prominent or sole initial symptom, then delaying diagnosis. Sleep/wake disorders in autoimmune encephalitis vary and include severe sleeplessness, hypersomnia, central and/or obstructive sleep apnea, rapid eye movement sleep behavior disorder, indeterminate sleep/wake states, and loss of circadian sleep/wake rhythms. N-methyl- d aspartate receptor encephalitis (NMDAR) is often associated with insomnia,...

  • Prevalence of pulmonary hypertension on echocardiogram in children with severe obstructive sleep apnea
    by Melissa A Maloney on February 25, 2022

    CONCLUSIONS: There was a relatively high prevalence of PH on echocardiogram in our cohort of children with severe OSA. The findings of increased PH prevalence among children with sleep-related hypoventilation or Down syndrome may help inform the development of targeted screening recommendations for specific pediatric OSA populations.

  • Clinical characteristics of patients with obstructive sleep apnea hypopnea syndrome combined with alveolar hypoventilation
    by Z J Wang on February 23, 2022

    Objective: To evaluate the clinical characteristics of patients with obstructive sleep apnea hypopnea syndrome (OSAHS) combined with alveolar hypoventilation. Methods: This retrospective study included patients who were diagnosed as OSAHS by polysomnography (PSG) and underwent daytime awake transcutaneous carbon dioxide (PtcCO(2)) monitoring from November 2019 to February 2021 at the Sleep Center of the Second Affiliated Hospital of Soochow University. A total of 177 patients were enrolled in...