Sedatives
A sedative or tranquilliser is a substance that induces sedation by reducing irritability or excitement. They are CNS depressants and interact with brain activity causing its deceleration. Various kinds of sedatives can be distinguished, but the majority of them affect the neurotransmitter gamma-aminobutyric acid.
Cluster Number:
Wiki Number: PW199
Diagnosis: Sedative (Tranquilizer)
US Patients: Works by reducing irritability or excitement. It is a Central Nervous System depressant causing brain activities’ deceleration.
World Patients: Most affect the GABA “neurotransmitter gamma-aminobutyric acid, relaxes by increasing GaBA activity. At higher doses it slurs one’s
Sex Ratio: speech, makes walking staggering, forces poor judgment and slows reflexes. Benzodiazapines can be used as an hypnotic for sleep.
Age Onset: When overused or comined an overdose can cause unconsciousness or death.
Brain Area: (1)an anxiolytic affects anxiety; (2)tranquilizer can refer to anxiolytic or antipsychotic; (3)soporific/sleeping pill mean hypnotics.
Symptoms: The article lists the types of sedatives: barbiturates, benzodiazepines, nonbenzodiazepine hypnotics, orexin antagonists,
Progression: first generation antihistamines, general anesthetics, herbal sedatives, methaqualone and analogues, skeletal muscle relaxants,
Causes: opioids, antidepressants, antipsychotics, and other. 124 individual sedatives are listed to prepare for surgery or other procedures.
Medications: In 2011, about half of US hospital admissions were from overuse of sedatives. Use can worsen psychiatric conditions like dementia,
Therapies: can cause amnesia. Some are dropped in bar-drinks before robberies and for date-rape.
Youtube Video: Pharmacology: Sedatives, Hypnotics & Anxiolytics
I was not able to find a book on sedatives on Amazon. Jim Lohr, Compiler
4 CURRENT ARTICLES
FROM PUBMED
The world-wide medical research
reports chosen for each diagnosis
Clicking each title opens the
PubMed article’s summary-abstract.
- Efficacy of the intravenous formulation of fentanyl citrate administered orally as premedication in paediatric patients undergoing open cardiac surgeryby Islam Mohamed Elbardan on December 20, 2024
CONCLUSIONS: A parenteral formulation of fentanyl can be a satisfactory alternative when given orally as a sedative pre-anaesthetic medication in paediatric cardiac surgery before admission to the operating room.
- The sedation efficacy of different doses of remimazolam in elderly patients with regional nerve block anaesthesiaby Wan-Jun Yang on December 20, 2024
CONCLUSION: The results indicated that doses of 5-5.5 mg remimazolam are more suitable for sedation in elderly patients, and the loss of consciousness time and depth of sedation differed according to the remimazolam dosage. Doses of 5-5.5 mg remimazolam were associated with adequate levels of sedation in elderly patients and with a decreased risk of complications, whilst haemodynamic fluctuations occurred approximately 12-15 min after the administration of remimazolam.
- Airway Management in Austere Settings: Intubation Is Not Always the Best Optionby Nicholas E Weinberg on December 20, 2024
Management of the airway in austere environments can differ substantially from standard in-hospital airway management. Devices such as nasopharyngeal airways, oropharyngeal airways, endotracheal tubes, extraglottic airways, ventilators, and sedative and paralytic medications may not be available. Weather, scene hazards, difficulties of extrication, transport times, skill sets of rescuers, and availability of advanced equipment are highly variable. Standard decision-making processes and...
- Patient demographics and psychotropic medication prescribing in Australian general practices: pre- and during COVID-19 pandemicby Getiye Dejenu Kibret on December 20, 2024
Introduction Mental health conditions, such as depression, anxiety, and psychological distress in the adult population significantly increased during the COVID-19 pandemic. However, the rates of prescribing psychotropic medications in adults during the COVID-19 period have not been well explored. Aim The aim of this study was to examine the association between demographic characteristics and rates of prescribing psychotropic medications to general practice patients during 2018-2022. Methods A...