Schizophrenia
Cluster Number:
Wiki Number: PW195
Diagnosis: Schizophrenia
US Patients: 1.1% of the population;Life expectancy decreased by 20 years; sedentary life leads to heart attacks;
World Patients: 20 million total cases; 16.7 Million-disabled due to schizophrenia, 75% unemployed; Violence-6X population; with alcohol-24X.
Sex Ratio: M+;F
Age Onset: M-early 20’s; F-late 20’s and post-menopausal in women. Psychosis (reality-unreality) often preceeds schizophrenia.
Brain Area: dopamine controls positive motivations; genes CRHR1 and CRHBP relate to suicidal behavior, several brain areas involved
Symptoms: Hallucinations, delusions, disorganized thinking, withdrawal, apathy, weak emotions, word salad; cognitively poorer generally
Progression: Usually non-violent; more likely to be victims,unless using alcohol or drugs.
Causes: 70-80% heritable; raised in city, older parents, drugs or pot used as teenager, several factors during pregnancy; childhood traumas
Medications: antipsychotics, hospitalization to stop harm to self or others, many create restlessness, muscle-jerking, weight gain
Therapies: exercise, CBTs, other talking therapies, along with medications, ½improve, some get well; the other half, life-time involvement.
Youtube Video: How Paranoid Schizophrenia Impacts My Life
Youtube Video: What is Schizophrenia?
Amazon or Library Book: Surviving Schizophrenia
Click the book to link or order from Amazon.
Support Group: sczaction.org 1-800-493-2094
(Schizophrenia Action Alliance)
Contact your local Social Security office for possible Disability Benefits under their Disability Determination Services,
Section 12.03.
4 CURRENT ARTICLES
FROM PUBMED
The world-wide medical research
reports chosen for each diagnosis
Clicking each title opens the
PubMed article’s summary-abstract.
- Evidence for Therapeutic Drug Monitoring of Atypical Antipsychoticsby Veronika Krejčí on May 18, 2024
Second-generation antipsychotics (SGAs), also known as atypical antipsychotics, are a newer class of antipsychotic drugs used to treat schizophrenia, bipolar disorder, and related psychiatric conditions. The plasma concentration of antipsychotic drugs is a valid measure of the drug at its primary target structure in the brain, and therefore determines the efficacy and safety of these drugs. However, despite the well-known high variability in pharmacokinetics of these substances, psychiatric...
- Elevated intrinsic cortical curvature in treatment-resistant schizophrenia: Evidence of structural deformation in functional connectivity areas and comparison with alternate indices of structureby Edgardo Torres-Carmona on May 18, 2024
CONCLUSION: ICC elevations were found among patients with TRS, and correlated with symptom severity. ICCs relative independence from sex, nicotine-use, and antipsychotics, may support ICC's potential as a viable marker for TRS, though age interactions should be considered.
- Modeling social cognition in alcohol use disorder: lessons from schizophreniaby Irene Perini on May 18, 2024
A better understanding of social deficits in alcohol use disorder (AUD) has the potential to improve our understanding of the disorder. Clinical research shows that AUD is associated with interpersonal problems and the loss of a social network which impedes response to treatment. Translational research between animal models and clinical research may benefit from a discussion of the models and methods that currently guide research into social cognition in AUD. We propose that research in AUD...
- Associations between fearlessness about death and suicidal ideation in individuals with psychosisby Jennifer Villa on May 18, 2024
BACKGROUND: Despite high rates of suicide among people with psychosis, relatively little is known about the mechanisms underlying the transition from suicidal ideation to behavior in this population. The Interpersonal Psychological Theory of Suicide (IPTS) proposes that fearlessness about death (FAD) may play a role in this relationship. The present study tested whether constructs of the IPTS [thwarted belongingness (TB), perceived burdensomeness (PB), and FAD] were associated with the severity...