Schizophrenia

A disorder that affects a person’s ability to think, feel, and behave clearly.

The exact cause of schizophrenia isn’t known, but a combination of genetics, environment, and altered brain chemistry and structure may play a role.

Schizophrenia is characterized by thoughts or experiences that seem out of touch with reality, disorganized speech or behavior, and decreased participation in daily activities. Difficulty with concentration and memory may also be present.

Treatment is usually lifelong and often involves a combination of medications, psychotherapy, and coordinated specialty care services.

Cluster Number:
Wiki Number: PW195
Diagnosis: Schizophrenia
US Patients: 1.1% of the population;Life expectancy decreased by 20 years; sedentary life leads to heart attacks;
World Patients: 20 million total cases; 16.7 Million-disabled due to schizophrenia, 75% unemployed; Violence-6X population; with alcohol-24X.
Sex Ratio: M+;F
Age Onset: M-early 20’s; F-late 20’s and post-menopausal in women. Psychosis (reality-unreality) often preceeds schizophrenia.
Brain Area: dopamine controls positive motivations; genes CRHR1 and CRHBP relate to suicidal behavior, several brain areas involved
Symptoms: Hallucinations, delusions, disorganized thinking, withdrawal, apathy, weak emotions, word salad; cognitively poorer generally
Progression: Usually non-violent; more likely to be victims,unless using alcohol or drugs.
Causes: 70-80% heritable; raised in city, older parents, drugs or pot used as teenager, several factors during pregnancy; childhood traumas
Medications: antipsychotics, hospitalization to stop harm to self or others, many create restlessness, muscle-jerking, weight gain
Therapies: exercise, CBTs, other talking therapies, along with medications, ½improve, some get well; the other half, life-time involvement.

CLICK HERE FOR THE FULL WIKIPEDIA ARTICLE.

Youtube Video: How Paranoid Schizophrenia Impacts My Life

Youtube Video: What is Schizophrenia?

Amazon or Library Book: Surviving Schizophrenia

Click the book to link or order from Amazon.

Support Group: sczaction.org 1-800-493-2094

(Schizophrenia Action Alliance)

Contact your local Social Security office for possible Disability Benefits under their Disability Determination Services,

Section 12.03.

4 CURRENT ARTICLES
FROM PUBMED

The world-wide medical research
reports chosen for each diagnosis

Clicking each title opens the
PubMed article’s summary-abstract.

Pellagra and Scurvy in a Patient With Relapsed Schizophrenia
by Vanessa Tran on February 22, 2025
No abstract
Unraveling Integration-Segregation Imbalances in Schizophrenia Through Topological High-Order Functional Connectivity
by Qiang Li on February 22, 2025
CONCLUSION: We discovered that topological high-order functional connectivity highlights brain network interactions compared to low-order functional connectivity. Furthermore, we observed alterations in specific brain regions associated with schizophrenia, as well as changes in brain network information integration and segregation in individuals with schizophrenia.
Plasma prolactin and symptoms of schizophrenia
by Johan Spoov on February 22, 2025
No abstract
Deep learning imputes DNA methylation states in single cells and enhances the detection of epigenetic alterations in schizophrenia
by Jiyun Zhou on February 22, 2025
DNA methylation (DNAm) is a key epigenetic mark with essential roles in gene regulation, mammalian development, and human diseases. Single-cell technologies enable profiling DNAm at cytosines in individual cells, but they often suffer from low coverage for CpG sites. We introduce scMeFormer, a transformer-based deep learning model for imputing DNAm states at each CpG site in single cells. Comprehensive evaluations across five single-nucleus DNAm datasets from human and mouse demonstrate...