CONCLUSIONS: This is the first study to identify homelessness as a predictor against clozapine use, which raises important clinical and ethical considerations. Our findings also add to the literature on clozapine prescribing discrepancies among ethnic-minority patients. Overall, clozapine remains underutilized as the gold-standard treatment for treatment-resistant schizophrenia-spectrum disorders, reinforcing a need to improve evidence-based prescribing.

CONCLUSION: This case study provides valuable insights into the manifestations and management of psychosis in patients with LMS. A multidisciplinary approach involving psychiatry, neurology, endocrinology, and metabolic care is essential for comprehensive treatment. We recommend genetic testing and counseling for the patient's family, particularly during family planning, with non-invasive prenatal testing (NIPT) for siblings after marriage. Further research is needed to develop targeted...

CONCLUSION: Psychotic presentations in Phelan-McDermid syndrome may qualitatively differ from schizophrenia. Although numerous antipsychotics may be efficacious in the treatment of Phelan-McDermid syndrome-associated psychosis, this review most importantly highlights the paucity of available high-quality evidence to guide treatment decisions in this respect, and as such indicates the need for more reports to be published.

CONCLUSION: Informal caregivers of PwMI in China experienced a high level of caregiving burden, depression, and anxiety. Urgent actions are needed to relieve caregiving burden, depression, and anxiety among informal caregivers of PwMI in China.