Restless Legs Syndrome

A condition characterized by a nearly irresistible urge to move the legs, typically in the evenings.

Restless legs syndrome typically occurs while sitting or lying down. It generally worsens with age and can disrupt sleep.

The main symptom is a nearly irresistible urge to move the legs.

Getting up and moving around helps the unpleasant feeling temporarily go away. Self-care steps, lifestyle changes, or medications may help.

Cluster Number:
Wiki Number: PW187
Diagnosis: Restless Legs Syndrome (
US Patients: 2-15% of the population, higher %s when along with some other difficulties.
World Patients:
Sex Ratio: M;F2
Age Onset: “Early Onset RLS” hereditary, starts before age 45 and worsens over time. Late-onset RLS starts suddenly after 45, doesn’t worsen’
Brain Area: genetic, autosomal dominant (only needs gene from one parent)
Symptoms: Long term-urging leg (and sometimes arm) movement; sensation/pain begins while awake but relaxing.
Progression: worsened by any surgery, but especially back surgery or injury
Causes: “motor restlessness” – worsen by relaxation, iron deficiency, dopamine changes, reduced leg-oxygen levels, some medications
Medications: gabapentin, opioids – when resistant to other medications
Therapies: regular exercise, good sleep practices, stopping smoking; stretching legs and walking bring temporary relief