Insomnia is a common sleep disorder that, owing to difficulties falling asleep or maintaining sleep and/or early morning awakening, causes daytime functional impairment. Other sleep disorders include sleep-related breathing disorders; sleep-related movement disorders, such as periodic limb movement disorder and restless legs syndrome; parasomnias, such as rapid eye movement sleep behavior disorder and sleepwalking; and central disorders of hypersomnolence, such as narcolepsy. This article...

Teriflunomide is an oral agent that has long been used to treat relapsing-remitting multiple sclerosis. Teriflunomide inhibits the rapid proliferation of T and B lymphocytes by inhibiting the activity of dihydroorotate dehydrogenase. Common side effects include headache, alanine aminotransferase level elevation, hair thinning, and arthralgia. Cases of restless legs syndrome (RLS) associated with the use of teriflunomide have not been previously reported; however, RLS is more frequently observed...

PURPOSE OF REVIEW: Cannabis sativa and constituent cannabinoids are in widespread use for the treatment of sleep disorders where many patients desire pharmacotherapy. Previous reviews highlight a lack of high-quality evidence to support the efficacy and long-term safety of cannabinoids in various conditions. We aim to provide an update of recent original research evaluating cannabinoid-based therapeutics in sleep disorders.

CONCLUSIONS: The present study presents factors that might account for individual differences in the response to exercise. Overall, our results suggest that milder cases of RLS (lower severity, absence of PLMs), people with secondary forms of RLS, and those with a lower BMI may perceive exercise as more beneficial for symptoms. These should be considered in exercise-based management aimed at managing symptoms as the collective body of research supports the benefits of exercise in adults with...