Cureus. 2025 Jun 9;17(6):e85649. doi: 10.7759/cureus.85649. eCollection 2025 Jun.

ABSTRACT

Background Migraine is a common neurological disorder with significant socioeconomic and personal impact. Recent research suggests a potential association between migraine and impulsivity, particularly in females. Objective This study aims to investigate the prevalence of impulsivity and its correlation with migraine-related disability in females with migraine. Methods This is a case-control study involving female patients aged 18-60 with migraine, recruited from neurology and psychiatry outpatient clinics. Standardized assessments, including Migraine Disability Assessment (MIDAS), Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder 7-item (GAD-7), Barratt Impulsiveness Scale Version 11 (BIS-11), and McLean Screening Instrument for Borderline Personality Disorder (MSI-BPD), were used to evaluate migraine disability, depression, anxiety, and impulsivity. Data analysis was performed using SPSS version 25 (IBM Corp., Armonk, NY, USA). Results There were a total of 149 participants (n=149) in the study, comprising 68 (n=68, 46%) migraine sufferers and 81 (n=81, 54.4%) controls. Migraine patients had significantly higher impulsivity (BIS-11: 34.67 ± 11.95 vs. 26.81 ± 2.99, p < 0.001) and a higher prevalence of borderline personality traits (MSI-BPD: 2.76 ± 2.65 vs. 1.23 ± 0.93, p < 0.01). Depression and anxiety were also significantly more common in the migraine group. Conclusion These findings suggest a strong association between migraine, impulsivity, and mood disorders, emphasizing the need for integrated psychological and neurological management in migraine patients.

PMID:40636627 | PMC:PMC12240610 | DOI:10.7759/cureus.85649