Placebo effects in mental disorders

Handb Clin Neurol. 2025;213:183-193. doi: 10.1016/B978-0-443-29884-4.00016-9.

ABSTRACT

This chapter delves into the multifaceted role of placebo effects in mental disorders, highlighting their impact on treatment outcomes across a spectrum of conditions, including depression, anxiety, schizophrenia, and bipolar disorder. Placebo responses, often seen as the intersection of psychological and physiological healing mechanisms, are critically examined through systematic reviews and meta-analyses that compare placebo effects to active treatments. The findings underscore substantial placebo effects, particularly in depression and anxiety, where these effects are often comparable to those of pharmacological interventions. The chapter also explores the variability of placebo effects across different disorders and the implications for clinical practice, suggesting that understanding these effects could lead to more tailored and effective therapeutic approaches. Additionally, the discussion includes the potential of open-label placebos, the influence of patient expectations, and the role of the clinician-patient relationship in enhancing treatment outcomes. By dissecting these elements, the chapter aims to pave the way for integrating placebo mechanisms into clinical practice, thereby enhancing the overall effectiveness of mental health treatments.

PMID:41161958 | DOI:10.1016/B978-0-443-29884-4.00016-9