Phencyclidine or phenylcyclohexyl piperidine, also known as angel dust among other names, is a drug used for its mind-altering effects. PCP may cause hallucinations, distorted perceptions of sounds, and violent behavior. As a recreational drug, it is typically smoked, but may be taken by mouth, snorted, or injected.
Wiki Number: PW165
Diagnosis: Phencyclidine-PCP Related Disorders
US Patients: 2017-3% used sometime in their lives; 36% moved on into schizophrenia.
Brain Area: Inhibits hyppocampus, cerebellum with prolonged use leading to memory loss; acts like dopamine in its receptors
Symptoms: Drug “angel-dust” for mind-altering, hallucinations, muted sounds, violent behavior; may have adverse effects or suicide.
Progression: Unpredictable brain-altering in the short term; long-term brain damage often occurred. Resembles a schizophrenic episode.
Causes: used recreationally
Medications: benzodiazopenes for agitation and seizures; antipsychotics
Therapies: None listed.
4 CURRENT ARTICLES
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PubMed article’s summary-abstract.
- Discrimination of motor and sensorimotor effects of phencyclidine and MK-801: Involvement of GluN2C-containing NMDA receptors in psychosis-like modelsby Mireia Tarrés-Gatius on May 13, 2022
Non-competitive NMDA receptor (NMDA-R) antagonists like ketamine, phencyclidine (PCP) and MK-801 are routinely used as pharmacological models of schizophrenia. However, the NMDA-R subtypes, neuronal types (e.g., GABA vs. glutamatergic neurons) and brain regions involved in psychotomimetic actions are not fully understood. PCP activates thalamo-cortical circuits after NMDA-R blockade in reticular thalamic GABAergic neurons. GluN2C subunits are densely expressed in thalamus and cerebellum....
- Ketamine: from prescription anaesthetic to New Psychoactive Substanceby Maria Rosaria Varì on May 11, 2022
Discovered in the United States of America (USA) in the 1960s, ketamine was introduced as an anaesthetic drug to specifically replace phencyclidine. Briefly, the substance moved from the medical world to recreational users, since it was discovered that intense psychedelic experiences were obtained with dosages lower than those prescribed for anesthesia. At the end of the 90's, circulated in London nightclubs as a drug itself and as counterfeit 3,4-methylenedioxymethamphetamine tablets. In 1997,...
- Targeting α6GABAA receptors as a novel therapy for schizophrenia: A proof-of-concept preclinical study using various animal modelsby Ming Tatt Lee on April 28, 2022
GABA(A) receptors containing α6 subunits (α6GABA(A)Rs) in the cerebellum have -been implicated in schizophrenia. It was reported that the GABA synthesizing enzymes were downregulated whereas α6GABA(A)Rs were upregulated in postmortem cerebellar tissues of patients with schizophrenia and in a rat model induced by chronic phencyclidine (PCP). We have previously demonstrated that pyrazoloquinolinone Compound 6, an α6GABA(A)R-highly selective positive allosteric modulator (PAM), can rescue the...
- Chronic oral olanzapine treatment but not haloperidol decreases [3H] MK-801 binding in the rat brain Independent of dietary conditionsby Leah Waldman on April 28, 2022
Haloperidol and olanzapine are first and second-generation antipsychotic (neuroleptic) medications approved to treat schizophrenia. Glutamate signaling is known to play an important role in the manifestation of schizophrenia symptoms, as phencyclidine, a non-competitive N-methyl-D-aspartate receptor (NMDAR) antagonist, replicates and exasperates these symptoms. While initial reports show that neuroleptic treatments can impact aspects of NMDAR expression, there is little attention on the...