X-linked hypophosphataemia (XLH) is a life-long phosphate-wasting disorder that causes skeletal deformities, pain, stiffness, and fatigue and impairs quality of life. Burosumab was approved for use in adults in 2020. We describe three adults with persistent XLH symptoms who received burosumab treatment in a real-world setting. Patients report improvements in pain, mobility, physical function, energy, fatigue, and mental wellbeing through patient-reported outcome measures, enriched with further...

INTRODUCTION: Eosinophilic esophagitis (EoE) is a chronic immune-mediated disorder characterized by eosinophilic infiltration of the esophageal mucosa.

Reward deficiency syndrome (RDS) is an umbrella term encompassing a wide array of addictive behaviors that affect individuals across diverse spectra of society. Our research group has conducted a plethora of studies investigating the utilization of KB220 and its various iterations for addressing RDS, including: dopamine homeostasis, brain areas associated with dopamine, functional connectivity, qEEG, reductions of cravings, relapse prevention and detoxification, opioid-seeking and attenuation of...

Cervicogenic dizziness (CGD) is a disorder in which dizziness arises from cervical spine dysfunction and is diagnosed after excluding other conditions. We present a case of a 27-year-old woman with a six-year history of dizziness, neck and cervicothoracic pain, and occipital-temporal-orbital headaches. The patient also experienced occasional severe, incapacitating episodes of dizziness with vomiting. Previous evaluations, including advanced imaging, had helped rule out central, otolithic, and...