Encephale. 2025 Nov 7:S0013-7006(25)00173-3. doi: 10.1016/j.encep.2025.09.002. Online ahead of print.
ABSTRACT
AIM: The aim of the present study was to assess the Odor Hedonic Profile (OHP) to evaluate its sensitivity in relation to the level of depression.
METHOD: The self-rating tool (OHP) related to everyday odors and recently validated in the general population is based on hedonic estimation without olfactory stimulation to avoid bias linked to odorant properties and experimental protocols. OHP scores in a population with a major depressive episode were compared to a non-depressed control population and a population with a moderate depressive state.
RESULTS: The results showed significant differences in OHP scores depending on the group of participants (depressed, moderately depressed, and control). The results also showed that significant differences in OHP scores are related to sex. In addition, the results showed that OHP scores were correlated with levels of depression, anxiety and pleasure experienced. Finally, the group of depressed participants showed more conservative and negative aliesthesia profiles than moderately depressed and non-depressed control participants.
DISCUSSION: This study shows that OHP can be used in different populations, especially in diseases with mood/emotional disturbances such as depression.
PMID:41206252 | DOI:10.1016/j.encep.2025.09.002
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