Novel Non-hallucinogenic Neurite Growth Compounds as 5-HT2A Agonists for Treating Stress-Related Disorders, Namely Depression, Anxiety, and PTSD

ACS Med Chem Lett. 2025 Jul 30;16(8):1524-1525. doi: 10.1021/acsmedchemlett.5c00440. eCollection 2025 Aug 14.

ABSTRACT

Provided herein are novel non-hallucinogenic neurite growth compounds as 5-HT2A agonists, pharmaceutical compositions, use of such compounds in treating stress-related disorders, namely depression, anxiety, and post-traumatic stress disorder (PTSD), and processes for preparing such compounds.

PMID:40832535 | PMC:PMC12358990 | DOI:10.1021/acsmedchemlett.5c00440