Lewy body dementia
Resources for Patients and Caregivers
Lewy body dementia (LBD) is a disease associated with abnormal deposits of a protein called alpha-synuclein in the brain. These deposits, called Lewy bodies, affect chemicals in the brain whose changes, in turn, can lead to problems with thinking, movement, behavior, and mood.
Wiki Number: 26-Lewy Bodies Disorder/Dementia
US Patients: American actor and comedian Robin Williams committed suicide in 2014 with Parkinson’s and Lewy Bodies.
Age Onset: after age 50 with life expectancy of 8 years after diagnosis
Brain Area: The SNCA gene encodes the alpha-synuclein protein which is a building-block of Lewy bodies.
Symptoms: acting out dreams, visual hallucinations, attention difficulties, slowness of movements
Progression: dementia and Parkinson’s patients may also be affected. Cause cognitive fluctuations.
Causes: clumps of protein form on brain neurons causing heart and digestive functions, low blood pressure and apathy.
Therapies: Cognitive training, deep-brain and transcranial direct current stimulations have been used.
Resources for Physicians, Counselors and Researchers
4 CURRENT ARTICLES
The world-wide medical research
reports chosen for each diagnosis
Clicking each title opens the
PubMed article’s summary-abstract.
- Lippia grata essential oil complexed with β-cyclodextrin ameliorates biochemical and behavioral deficits in an animal model of progressive parkinsonismby Jose Ivo A Beserra-Filho on July 2, 2022
Parkinson's disease (PD) is identified by the loss of dopaminergic neurons in the Substantia Nigra pars compacta (SNpc), and is correlated to aggregates of proteins such as α-synuclein, Lewy's bodies. Although the PD etiology remains poorly understood, evidence suggests a main role of oxidative stress on this process. Lippia grata Schauer, known as "alecrim-do-mato", "alecrim-de-vaqueiro", "alecrim-da-chapada", is a native bush from tropical areas mainly distributed throughout the Central and...
- Autopsy Human Brain Dissection Protocol for Common Age-Related Neurodegenerative Disordersby Joshua A Sonnen on July 1, 2022
Age-related neurodegenerative disorders are common causes of dementia-associated morbidity and mortality in populations throughout the world. Standardized, protocol-based methods for the examination and diagnosis of these disorders allow direct comparison between human cohorts and play a key role in understanding how these disorders impact our population. Further understanding of these protocols and harmonization with animal and in vitro investigative techniques is imperative to demonstrate...
- LDL cholesterol is associated with higher AD neuropathology burden independent of APOEby Aliza P Wingo on June 30, 2022
CONCLUSIONS: These findings implicate LDL-C in the pathophysiology of AD independent of APOE and suggest LDL-C is a modifiable risk factor for AD.
- Prevalence of potentially inappropriate medications among old people with major neurocognitive disorder in 2012 and 2017by Iris Rangfast on June 30, 2022
CONCLUSIONS: Overall, the use of PIMs decreased between the years 2012 and 2017. The increase of antipsychotic drugs and the association between PIM use and multi-dispensed drugs warrant concern.