Hyperkinesia
Abnormally increased and sometimes uncontrollable activity or muscular movements. 2 : a condition especially of childhood characterized by hyperactivity
Cluster Number:
Wiki Number: W097
Diagnosis: Hyperkinesia
US Patients:
World Patients:
Sex Ratio:
Age Onset:
Brain Area: The subthalamic nucleus improperly controls the basal ganglia producing these involuntary, unwanted movements.
Symptoms: several variations of excessive, unwanted muscle movements: ataxia, athetosis, chorea, dystonias, hemiballismus,
Progression: hemifacial spasms, myoclonus, stereotypies, tremors, tics, and volitional hyperkinesia; all are subsets of movements
Causes: Oversensitivity of dopamine and norepinephrine receptors or hyperactivity of the dopaminergic receptors appear.
Medications: Vary by diagnosis.
Therapies: Vary by diagnosis.
Youtube Video: Diagnosing and Treating
Hyperkinetic Movement Disorders
Amazon or Library Book: Hyperkinetic Children (Kindle Only)
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It is only available in a Kindle edition.
4 CURRENT ARTICLES
FROM PUBMED
The world-wide medical research
reports chosen for each diagnosis
Clicking each title opens the
PubMed article’s summary-abstract.
- Insights into RNA-mediated pathology in new mouse models of Huntington's diseaseby Magdalena Wozna-Wysocka on November 28, 2024
Huntington's disease (HD) is a neurodegenerative polyglutamine (polyQ) disease resulting from the expansion of CAG repeats located in the ORF of the huntingtin gene (HTT). The extent to which mutant mRNA-driven disruptions contribute to HD pathogenesis, particularly in comparison to the dominant mechanisms related to the gain-of-function effects of the mutant polyQ protein, is still debatable. To evaluate this contribution in vivo, we generated two mouse models through a knock-in strategy at the...
- Cardiac manifestations of prolonged seizure: A case report on reverse takotsubo syndrome and neurogenic stunned myocardiumby Atef Akoum on November 14, 2024
Seizures, characterized by excessive electrical discharges in the brain, can lead to severe complications, including cardiac arrhythmias and Takotsubo syndrome, a form of stress-induced cardiomyopathy mimicking acute coronary syndrome. We present a case of a 66-year-old female with epilepsy and postcerebrovascular accident status who experienced a 45-minute seizure resulting in elevated troponin levels and ECG changes. Echocardiography revealed severe hypokinesia and hyperkinesia with a left...
- Rhynchophylline Alleviates Hyperactivity and Cognitive Flexibility Impairment Associated With Inhibition of Inflammatory Responses in Mice That Partly Lack the Dopamine Transporter Proteinby Jijun Li on November 12, 2024
CONCLUSION: RHY improved hyperactivity and cognitive flexibility impairment through inhibiting inflammatory responses in DAT- mice.
- Impaired striatal glutathione-ascorbate metabolism induces transient dopamine increase and motor dysfunctionby Mohd Yaseen Malik on October 29, 2024
Identifying initial triggering events in neurodegenerative disorders is critical to developing preventive therapies. In Huntington's disease (HD), hyperdopaminergia-probably triggered by the dysfunction of the most affected neurons, indirect pathway spiny projection neurons (iSPNs)-is believed to induce hyperkinesia, an early stage HD symptom. However, how this change arises and contributes to HD pathogenesis is unclear. Here, we demonstrate that genetic disruption of iSPNs function by...