Huntington’s Disease
Huntington’s disease (HD) is a fatal genetic disorder that causes the progressive breakdown of nerve cells in the brain. It deteriorates a person’s physical and mental abilities usually during their prime working years and has no cure.
Cluster Number:
Wiki Number: W096
Diagnosis: Huntington’s Disease
US Patients:
World Patients:
Sex Ratio:
Age Onset: 30-50 years; The patient ultimately dies from the disease.
Brain Area: striatum (center)is affected first; then effects move out to damage other areas; caudate nucleus & putamen-brain center.
Symptoms: unsteady walking & lack of coordination. “chorea” = jerky, uncontrollable movements; saccadic (darting) eye movements
Progression: unable to talk; loss of decision-making and memory=lead to dementia; suicidal thoughts
Causes: gene from a parent, but 10% are new mutation; the mutant damages brain cells; genes do not skip generations.
Medications:
Therapies: stem-cells to replace lost neurons; Huntington’s is too complex to explain fairly here. It is both awful and fatal in the end.
Youtube Video:
Huntington’s Disease Treatment
Youtube Video: Living with Juvenile Huntington’s Disease
Amazon or Library Book: 2019 Huntington’s Disease
Click the book to link or order from Amazon.
Support Group: hdsa.org; huntingtonassoc.com
(Huntington’s Disease Society of America)
Contact your local Social Security office for possible Disability Benefits through their Disability Determination Services,
Section 12.02.
4 CURRENT ARTICLES
FROM PUBMED
The world-wide medical research
reports chosen for each diagnosis
Clicking each title opens the
PubMed article’s summary-abstract.
- The traditional uses, pharmacology, and phytochemistry of Peucedanum praeruptorum Dunnby Qiongxiao Wang on April 18, 2024
Bai Hua Qian Hu (Qianhu; Peucedanum praeruptorum Dunn) is a classical medicinal plant traditionally prescribed for respiratory ailments, including cough, pulmonary hypertension, and asthma. In this review, we summarize the research progress of the toxicology, pharmacokinetics, pharmacology, phytochemistry, botany, quality control, and traditional uses of P. praeruptorum in order to support future investigations into the scientific and therapeutic promise of this important medicinal plant....
- Investigating the Therapeutics Effects of Oral Cavity Derived Stem Cells on Neurodegenerative Diseases: A Systematic Reviewby Emel Uzunoglu-Ozyurek on April 17, 2024
CONCLUSION: Although studies reported favorable data regarding the OCDSCs on NDs, they presented a considerable risk of bias. Because of heterogeneous study characteristics, the current study recommends improving standardized methods to evaluate the therapeutic effects of OCDSCs on the NDs.
- Gastrointestinal disorders in hyperkinetic movement disorders and ataxiaby Inga Claus on April 17, 2024
Disorders of the gastrointestinal tract in patients suffering from hypokinetic movement disorders, and in particular Parkinson's disease, have increasingly been the subject of more intensive neuromedical research. So far, few data are available for patients with hyperkinetic movement disorders and ataxias. This review article summarizes the currently available and relevant publications on this topic. The particular focus is on essential tremor, restless legs syndrome, Huntington's disease and...
- Gangliosides as Therapeutic Targets for Neurodegenerative Diseasesby Orhan Kerim Inci on April 16, 2024
Gangliosides, sialic acid-containing glycosphingolipids, are abundant in cell membranes and primarily involved in controlling cell signaling and cell communication. The altered ganglioside pattern has been demonstrated in several neurodegenerative diseases, characterized during early-onset or infancy, emphasizing the significance of gangliosides in the brain. Enzymes required for the biosynthesis of gangliosides are linked to several devastating neurological disorders, including Alzheimer's...