Huntington’s disease (HD) is a fatal genetic disorder that causes the progressive breakdown of nerve cells in the brain. It deteriorates a person’s physical and mental abilities usually during their prime working years and has no cure.
Wiki Number: W096
Diagnosis: Huntington’s Disease
Age Onset: 30-50 years; The patient ultimately dies from the disease.
Brain Area: striatum (center)is affected first; then effects move out to damage other areas; caudate nucleus & putamen-brain center.
Symptoms: unsteady walking & lack of coordination. “chorea” = jerky, uncontrollable movements; saccadic (darting) eye movements
Progression: unable to talk; loss of decision-making and memory=lead to dementia; suicidal thoughts
Causes: gene from a parent, but 10% are new mutation; the mutant damages brain cells; genes do not skip generations.
Therapies: stem-cells to replace lost neurons; Huntington’s is too complex to explain fairly here. It is both awful and fatal in the end.
4 CURRENT ARTICLES
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PubMed article’s summary-abstract.
- Targeted protein degradation using intracellular antibodies and its application to neurodegenerative diseaseby Jonathan A Benn on October 16, 2021
Antibodies mediate the majority of their effects in the extracellular domain, or in intracellular compartments isolated from the cytosol. Under a growing list of circumstances, however, antibodies are found to gain access to the cytoplasm. Cytosolic immune complexes are bound by the atypical antibody receptor TRIM21, which mediates the rapid degradation of the immune complexes at the proteasome. These discoveries have informed the development of TRIM-Away, a technique to selectively deplete...
- Gene Therapy Approach with an Emphasis on Growth Factors: Theoretical and Clinical Outcomes in Neurodegenerative Diseasesby Della Grace Thomas Parambi on October 16, 2021
The etiology of many neurological diseases affecting the central nervous system (CNS) is unknown and still needs more effective and specific therapeutic approaches. Gene therapy has a promising future in treating neurodegenerative disorders by correcting the genetic defects or by therapeutic protein delivery and is now an attraction for neurologists to treat brain disorders, like Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, spinal muscular atrophy, spinocerebellar...
- Off-resonance saturation as an MRI method to quantify mineral- iron in the post-mortem brainby Lucia Bossoni on October 16, 2021
CONCLUSIONS: Off-resonance saturation is an effective way to detect iron in gray matter structures and partially mitigate for the presence of myelin. If a reference region with little iron is available in the tissue, the method can produce quantitative iron maps. This method is applicable in the study of diseases characterized by brain iron accumulation and can complement existing iron-sensitive parametric methods.
- Withania somnifera (L.) Dunal (Ashwagandha): A comprehensive review on ethnopharmacology, pharmacotherapeutics, biomedicinal and toxicological aspectsby Subhabrata Paul on October 15, 2021
Withania somnifera (L.) Dunal (Solanaceae) has been used as a traditional Rasayana herb for a long time. Traditional uses of this plant indicate its ameliorative properties against a plethora of human medical conditions, viz. hypertension, stress, diabetes, asthma, cancer etc. This review presents a comprehensive summary of the geographical distribution, traditional use, phytochemistry, and pharmacological activities of W. somnifera and its active constituents. In addition, it presents a...