Braz J Psychiatry. 2025 Oct 31. doi: 10.47626/1516-4446-2025-4560. Online ahead of print.
ABSTRACT
AIM: This study aimed to characterize response trajectories in MDD patients and identify clinical and demographic predictors for symptom alleviation.
METHODS: This study was a secondary analysis of the longitudinal data collected from 10 governances of China from 9th November 2016 to 30th December 2020. The depressive symptoms were mainly measured using the 17-item Hamilton Depression Rating Scale (HAMD-17). Group-based trajectory modeling (GBTM) identified symptom trajectories from baseline to week 24.
RESULTS: A total of 1438 participants were included. Two trajectories were identified: 74.27% of participants belonging to trajectory 1 labeled as the “rapid decline trajectory”; this trajectory was characterized by moderate depression followed by a rapid decrease after treatment. And 25.73% of participants belonging to trajectory 2 labeled as the “late decline trajectory”; this trajectory was characterized by severe depression and a gradual decline over 24 weeks. Compared with those in the rapid decline trajectory, the values including the HAMD-17 total score at baseline, the proportion of female participants, and the duration of untreated episodes were significantly higher in the late decline trajectory.
CONCLUSIONS: Distinct response trajectories were identified in patients with MDD. Milder baseline severity, shorter untreated episodes, and male sex predicted rapid responses, aiding in treatment guidance.
PMID:41172324 | DOI:10.47626/1516-4446-2025-4560
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