General Adaptation Syndrome

The general adaptation syndrome (GAS), developed by Hans Selye, describes the pattern of responses that the body goes through after being prompted by a stressor. There are three stages: alarm, resistance, and exhaustion.

 

Cluster Number:
Wiki Number: W089
Diagnosis: General Adaptation Syndrome
US Patients:
World Patients:
Sex Ratio:
Age Onset:
Brain Area: amygdala, hypothalamus, limbic system, stria terminalis, prefrontal cortex; the autonomic nervous system takes over
Symptoms: lack of coping resources to chronic stress can lead to delusions, depression and anxiety, raise serum lipids vs. heart attacks
Progression: alarm(shock&(antishock-locus coeruleus); resistancea, and exhaustion-return to homeostaisis unless chronic-PTSD
Causes: sympathetic nervous system (like “speech anxiety”) and the hypothalmic nervous system-fight-flight releasing cortisol
Medications: None Listed
Therapies: Learning coping strategies reduces stress;acute stress, short duration; (may be milder) stress, long enough to be chronic

Youtube Video: Stress and the HPA Axis

Amazon or Library Book: Human Adaptation to Extreme Stress

Click your book to link or order from Amazon.

4 CURRENT ARTICLES
FROM PUBMED

The world-wide medical research
reports chosen for each diagnosis 

Clicking each title opens the
PubMed article’s summary-abstract.

  • Relying on the French territorial offer of thermal spa therapies to build a care pathway for long COVID-19 patients
    by Milhan Chaze on April 19, 2024

    CONCLUSION: Based on the example of the French spa offer, this study makes it possible to place the care pathways of long COVID-19 patients in a wider area (at least national), rather than limiting them to clinical and local management in a hospital setting. The identification and operationalization of two geographical criteria for integrating a type of treatment such as a spa cure into a care pathway contributes to a finer conceptualization of the construction of healthcare pathways.

  • Hungarian adaptation of the cerebellar cognitive affective/Schmahmann Syndrome Scale
    by Viktória Szabó-Műhelyi on April 18, 2024

    Recent studies have reported that cerebellar lesions can cause cognitive, behavioral, and affective symptoms. This constellation is called the cerebellar cognitive affective syndrome (CCAS). A bedside instrument, the CCAS-Scale, has been developed to screen for this clinical presentation. The aim of this study is to adapt the CCAS-Scale to Hungarian according to international cross-cultural guidelines. In cooperation with the senior author of the original CCAS-Scale, we defined a five-step...

  • What is quality in long covid care? Lessons from a national quality improvement collaborative and multi-site ethnography
    by Trisha Greenhalgh on April 14, 2024

    CONCLUSION: Not all variation in long covid services is unwarranted. Largely because long covid's manifestations are so varied and comorbidities common, generic "evidence-based" standards require much individual adaptation. In this complex condition, quality improvement resources may be productively spent supporting MDTs to optimise their case-based learning through interdisciplinary discussion. Quality assessment of a long covid service should include review of a sample of individual cases to...

  • Interferon Upregulation Associates with Insulin Resistance in Humans
    by Maria M Adeva-Andany on March 19, 2024

    In humans, insulin resistance is a physiological response to infections developed to supply sufficient energy to the activated immune system. This metabolic adaptation facilitates the immune response but usually persists after the recovery period of the infection and predisposes the hosts to type 2 diabetes and vascular injury. In patients with diabetes, superimposed insulin resistance worsens metabolic control and promotes diabetic ketoacidosis. Pathogenic mechanisms underlying insulin...