Frontotemporal Cognitive Disorder
Resources for Patients and Caregivers
Frontotemporal disorders (FTD), sometimes called frontotemporal dementia, are the result of damage to neurons in the frontal and temporal lobes of the brain. Many possible symptoms can result, including unusual behaviors, emotional problems, trouble communicating, difficulty with work, or difficulty with walking.
Cluster Number:
Wiki Number: 19-Frontotemporal Cognitive Disorder
Diagnosis:
US Patients:
World Patients:
Sex Ratio:
Age Onset:
Brain Area: frontal lobe
Symptoms: difficulties with cognitive (movement and speech), emotional or behavioral activities
Progression:
Causes: brain injuries, frontotemporal-dementia or Alzheimer’s diseases
Medications:
Therapies: speech therapy
Youtube Video: 60 Minutes Archive: Frontotemporal Dementia
Amazon or Library Book: Frontotemporal Related Dementias
Click the book to link or order from Amazon.
Support Group: info@theaftd.com; 866-507-7222
(Association for Frontotemporal Degeneration)
Resources for Physicians, Counselors and Researchers
4 CURRENT ARTICLES
FROM PUBMED
The world-wide medical research
reports chosen for each diagnosis
Clicking each title opens the
PubMed article’s summary-abstract.
- Mark4 ablation attenuates pathological phenotypes in a mouse model of tauopathyby Grigorii Sultanakhmetov on May 7, 2024
Accumulation of abnormally phosphorylated tau proteins is linked to various neurodegenerative diseases, including Alzheimer's disease and frontotemporal dementia. Microtubule affinity-regulating kinase 4 (MARK4) has been genetically and pathologically associated with Alzheimer's disease and reported to enhance tau phosphorylation and toxicity in Drosophila and mouse traumatic brain-injury models but not in mammalian tauopathy models. To investigate the role of MARK4 in tau-mediated...
- Visuospatial working memory in behavioural variant frontotemporal dementia: a comparative analysis with Alzheimer's disease using the box taskby David Foxe on May 7, 2024
CONCLUSIONS: Our findings reveal significant visuospatial working memory impairments in bvFTD, albeit of lesser severity compared to disease-matched AD patients. The Box Task, a novel measure of visuospatial working memory, proved effective in differentiating between bvFTD and AD, outperforming many traditional neuropsychological measures. Overall, our findings highlight the utility of assessing visuospatial memory when differentiating between bvFTD and AD in the clinical setting.
- Examining the relation between bilingualism and age of symptom onset in frontotemporal dementiaby Jessica de Leon on May 6, 2024
Bilingualism is thought to confer advantages in executive functioning, thereby contributing to cognitive reserve and a later age of dementia symptom onset. While the relation between bilingualism and age of onset has been explored in Alzheimer's dementia, there are few studies examining bilingualism as a contributor to cognitive reserve in frontotemporal dementia (FTD). In line with previous findings, we hypothesized that bilinguals with behavioral variant FTD would be older at symptom onset...
- A novel MAPT variant (E342K) as a cause of familial progressive supranuclear palsyby Hang Li on May 6, 2024
CONCLUSION: The PSP pedigree caused by the novel MAPT (E342K) variant, expanded the mutational spectrum of MAPT.