Frontotemporal Cognitive Disorder
Resources for Patients and Caregivers
Frontotemporal disorders (FTD), sometimes called frontotemporal dementia, are the result of damage to neurons in the frontal and temporal lobes of the brain. Many possible symptoms can result, including unusual behaviors, emotional problems, trouble communicating, difficulty with work, or difficulty with walking.
Cluster Number:
Wiki Number: 19-Frontotemporal Cognitive Disorder
Diagnosis:
US Patients:
World Patients:
Sex Ratio:
Age Onset:
Brain Area: frontal lobe
Symptoms: difficulties with cognitive (movement and speech), emotional or behavioral activities
Progression:
Causes: brain injuries, frontotemporal-dementia or Alzheimer’s diseases
Medications:
Therapies: speech therapy
Resources for Physicians, Counselors and Researchers
4 CURRENT ARTICLES
FROM PUBMED
The world-wide medical research
reports chosen for each diagnosis
Clicking each title opens the
PubMed article’s summary-abstract.
- Proteinopathies associated to repeat expansion disordersby Anthony Fourier on January 24, 2022
The most common neurodegenerative disorders, such as Alzheimer's or Parkinson's diseases, are characterized by synaptic dysfunction, neuronal loss and proteinaceous aggregates in central nervous system. The deposition of misfolded proteins constitutes neuropathological hallmarks of these diseases, grouped in the generic term of proteinopathies. Apart from these, other neurodegenerative diseases are characterized by genetic abnormalities like unstable repetitive simple sequence tracts...
- An Automated Toolbox to Predict Single Subject Atrophy in Presymptomatic Granulin Mutation Carriersby Enrico Premi on January 24, 2022
CONCLUSION: The preGRN-MRI tool, using baseline MRI measures, was able to predict the expected MRI atrophy at follow-up in presymptomatic subjects carrying GRN mutations with good performances. This tool could be useful in clinical trials, where deviation of CT from the predicted model may be considered an effect of the intervention itself.
- White matter microstructure alterations in frontotemporal dementia: Phenotype-associated signatures and single-subject interpretationby Mary Clare McKenna on January 24, 2022
CONCLUSIONS: Our findings suggest that it is possible to meaningfully evaluate the diffusion profile of single FTD patients if large normative datasets are available. In contrast to the visual review of FLAIR and T2-weighted images, computational imaging offers objective, quantitative insights into white matter integrity changes even at single-subject level.
- Impact of long- and short-range fiber depletion on the cognitive deficits of fronto-temporal dementiaby Melissa Savard on January 24, 2022
Recent studies suggest a framework where white matter (WM) atrophy plays an important role in fronto-temporal dementia (FTD) pathophysiology. However, these studies often overlook the fact that WM tracts bridging different brain regions may have different vulnerabilities to the disease and the relative contribution of GM atrophy to this WM model, resulting in a less comprehensive understanding of the relationship between clinical symptoms and pathology. Using a common factor analysis to extract...