Efficacy of a short-term physical exercise intervention on stress biomarkers and mental health in adolescents with ADHD: A randomized controlled trial

J Affect Disord. 2025 Sep 11:120285. doi: 10.1016/j.jad.2025.120285. Online ahead of print.

ABSTRACT

BACKGROUND: Adolescence is a pivotal stage of psychological and biological change affecting mental health. Adolescents with ADHD are especially vulnerable and often show lower baseline cortisol. Although physical exercise is a promising strategy for improving well-being, research on stress biomarkers in this population remains scarce. This study aimed to examine the effects of a PE intervention on self-reported stress, anxiety, and depression, alongside salivary cortisol levels.

METHODS: In a two-armed randomized controlled trial, 82 adolescents with ADHD (aged 12-17 years, Mage = 14.38 ± 1.18) were assigned to either a 3-week PE program (n = 45) with moderate-to-vigorous intensity (two 90-min sessions per week, 540 min in total) or to a control group (CG; n = 37). Self-reported levels of stress, anxiety, and depression, along with salivary cortisol levels, were assessed at three-time points: baseline, immediately after the intervention, and three months post-intervention follow-up.

RESULTS: The generalized estimated equation analysis revealed significant group-by-time interactions for self-reported stress and cortisol levels. Compared to baseline, self-reported stress levels were significantly decreased (MD_adj = -0.45, 95 % CI = -0.82 to -0.09, p = 0.009), while salivary cortisol levels were significantly increased (MD_adj = 0.09, 95 % CI = 0.01 to 0.17, p = 0.02) immediately post-intervention. None of these effects persisted after three-month post-intervention follow-up.

CONCLUSION: Short-term PE appears to be an effective approach for reducing self-reported stress levels and increasing cortisol levels in adolescents with ADHD.

PMID:40945770 | DOI:10.1016/j.jad.2025.120285