Disruptive Mood Dysregulation Disorder
Disruptive mood dysregulation disorder (DMDD) is a childhood condition of extreme irritability, anger, and frequent, intense temper outbursts. DMDD symptoms go beyond a being a “moody” child—children with DMDD experience severe impairment that requires clinical attention.
Cluster Number:
Wiki Number: W066
Diagnosis: Disruptive Mood Dysregulation Disorder
US Patients: 1.5% children
World Patients:
Sex Ratio:
Age Onset: Child or adolescent
Brain Area: under-activity of the amygdala at judging other’s anger or sadness; medial front gyrus and anterior cingulate cortex – lower
Symptoms: disproportionate irritable or angry moods or several temper outbursts weekly; poor stress regulation; one year or more
Progression: displays persistent anger against people and objects, often have anxiety and depression in later years
Causes: Brain areas above are important for evaluating and regulating negative emotions; poverty and single-parenthood affect it
Medications: antidepressants, antipsychotics and mood stabilizers
Therapies: None listed.
Youtube Video: Treatment Challenges of Impulse Control
Behavioral Disorder
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4 CURRENT ARTICLES
FROM PUBMED
The world-wide medical research
reports chosen for each diagnosis
Clicking each title opens the
PubMed article’s summary-abstract.
- Dysregulation of the endogenous cannabinoid system following opioid exposureby Ardavan Mohammad Aghaei on November 6, 2023
Rates of opioid-related deaths and overdoses in the United States are at record-high levels. Thus, novel neurobiological targets for the treatment of OUD are greatly needed. Given the close interaction between the endogenous opioid system and the endocannabinoid system (ECS), targeting the ECS may have therapeutic potential in OUD. The various components of the ECS, including cannabinoid receptors, their lipid-derived endogenous ligands (endocannabinoids [eCBs]), and the related enzymes, present...
- Hard-to-treat or hard-to-catch? Clinical features and therapeutic outcomes of help-seeking foster care youths with mood disordersby Xavier Benarous on October 30, 2023
INTRODUCTION: The high level of emotional problems in youths placed in foster care contrasts with the limited use of evidence-based treatments. This study aims to better characterize the clinical features and therapeutic outcomes of foster care youths with mood disorders.
- Mediating effect of amygdala activity on response to fear vs. happiness in youth with significant levels of irritability and disruptive mood and behavior disordersby Ji-Woo Suk on October 30, 2023
INTRODUCTION: Irritability, characterized by a tendency to exhibit increased anger, is a common clinical problem in youth. Irritability is a significant clinical issue in youth with various psychiatric diagnoses, especially disruptive behavior, and mood disorders (Attention-Deficit/Hyperactivity Disorder, Oppositional Defiant Disorder, Conduct Disorder, and Disruptive Mood Dysregulation Disorder). Although there have been previous studies focusing on functional alteration in the amygdala related...
- Characteristic Similarities of Irritability Between Autism and Disruptive Mood Dysregulation Disorderby Pei-Yin Pan on October 26, 2023
Objective: Irritability in children with autism spectrum disorder (ASD) is prominent and often leads to distress to both autistic children and their families. However, the nature of irritability in autism and the difference from nonautistic children have rarely been examined. This study aimed to investigate the clinical characteristics of irritability in autism, and to compare the symptom profiles with those of disruptive mood dysregulation disorder (DMDD) in nonautistic children. Methods:...