CONCLUSIONS: Overall, prenatal EDC exposure altered behavior, hormones, and brain monoamines, with adult E2 treatment further exacerbating some of these effects in female offspring.

TAR DNA-binding protein (TDP-43) and Metastasis Associated Lung Adenocarcinoma Transcript (MALAT1) RNA are both abundantly expressed in the human cell nucleus. Increased interaction of TDP-43 and MALAT1, as well as dysregulation of TDP-43 function, was previously identified in brain samples from patients with neurodegenerative disease compared to healthy brain tissues. We hypothesized that TDP-43 function may depend in part on MALAT1 expression levels. Here, we find that alterations in MALAT1...

CONCLUSION: Children and adolescents diagnosed with DMDD demonstrated significantly lower scores in anticipatory worry, fear of uncertainty, shyness, fatigability, sentimentality, dependence, empathy, and helpfulness compared to those with MDD. Conversely, they exhibited higher levels of impulsiveness, disorderliness, and self-acceptance. These findings underscore the necessity of evaluating and enhancing social skills and reward sensitivity in the clinical management of DMDD, as these distinct...

CONCLUSIONS: In youth with ADHD, a DMDD diagnosis is associated with increases in the spectrum of pharmacological and nonpharmacological treatments deployed with patterns varying by race and ethnicity. Antipsychotic and mood stabilizer prescriptions increased most prominently, often before receiving psychotherapy services or efforts to optimize ADHD medication. Future research should address disparities in DMDD treatment patterns and identify the optimal treatment sequences for DMDD.