Cocaine Dependence
Cocaine dependence is a biopsychosocial disorder characterized by persistent use of cocaine despite substantial harm and adverse consequences.
Cluster Number:
Wiki Number: W044
Diagnosis: Cocaine Dependence
US Patients: 6000 deaths annually
World Patients:
Sex Ratio: M;W3
Age Onset: 13-4X vs. 19
Brain Area: overdoses can constrict blood vessels in the brain and heart – causing damage
Symptoms: positively-high energy; negatively-high body temperatures, irregular heart beat, death, amphetamine psychosis,
Progression: large doses cause mood swings, paranoia, insomnia, psychosis, high blood pressure, panic attacks, cognitive impairments
Causes: 15% of users become dependent in two years
Medications: None investigated were effective.
Therapies: 12-Step Cocaine Anonymous; CBT – both have low success rates
Youtube Video: What’s Cocaine Addiction Like?
Amazon (Only on Audible), but maybe the Library has it also:
The Small Book . . Alcohol and Drug Dependence
Amazon or Library Book:
Chasing the Scream
Click the book to link or buy from Amazon.
Click the book to link or buy from Amazon.
Support Group: ca.org; Cocaine Anonymous
(Contact phone numbers are available in most states.)
4 CURRENT ARTICLES
FROM PUBMED
The world-wide medical research
reports chosen for each diagnosis
Clicking each title opens the
PubMed article’s summary-abstract.
- A Randomized Controlled Trial of Medial Prefrontal Cortex Theta Burst Stimulation for Cocaine Use Disorder: A Three-Month Feasibility and Brain Target-Engagement Studyby Daniel M McCalley on December 12, 2024
CONCLUSIONS: This early-stage trial demonstrates TBS to the MPFC reduces brain reactivity to cocaine cues in key nodes of the Salience Network in treatment-seeking cocaine users. Future, well-powered trials are warranted to evaluate clinical efficacy outcomes.
- Long- vs short-access cocaine alters behavioral inhibition for cocaine in male ratsby Taena Hanson on December 7, 2024
Impulsivity and behavioral inhibition are measures commonly associated with substance misuse, particularly cocaine use disorder. However, patterns of impulsive behaviors have been shown to differ based on cocaine use history and level of cocaine dependence. Extended cocaine access, which more closely models neural and behavioral changes that take place during the development of problematic cocaine use, has been shown to decrease behavioral inhibition in comparison to limited cocaine access....
- Methylphenidate abuse and misuse in patients affected with a psychiatric disorder and a substance use disorder: a systematic reviewby Stefania Chiappini on December 3, 2024
CONCLUSION: MPH misuse and abuse are significant concerns in patients with psychiatric disorders and SUD. Risk factors include impulsivity, history of substance abuse, and access to prescription stimulants. Integrated therapeutic approaches and stricter prescription monitoring are recommended to mitigate misuse risks.
- Individual differences in prelimbic neural representation of food and cocaine seekingby Joseph T Glanzberg on November 28, 2024
The prelimbic cortex is involved in operant reward seeking. However, the precise nature of its activity patterns and whether/how they differ between different types of rewards are largely unknown. We use miniscope calcium imaging to observe prelimbic activity during both food and cocaine seeking in freely behaving mice. We find that neurobehavioral representations remain stable across days within individual mice. Unexpectedly, our data reveal significant individual differences: some mice display...