Salt-inducible kinase 1 and CREB-regulated transcription co-activator 1 in the paraventricular nucleus participate in the antidepressant-like mechanism of (2R, 6R)-hydroxynorketamine and (2S, 6S)-hydroxynorketamine in mice

Neuropharmacology. 2025 Aug 9:110632. doi: 10.1016/j.neuropharm.2025.110632. Online ahead of print. ABSTRACT BACKGROUND: Previous studies have demonstrated that ketamine’s metabolic conversion to (2S, 6S; 2R, 6R)-HNK is indispensable for its fast-onset and...