by jlohrconsulting | Aug 20, 2025 | Uncategorized
ACS Med Chem Lett. 2025 Jul 28;16(8):1507-1508. doi: 10.1021/acsmedchemlett.5c00426. eCollection 2025 Aug 14. ABSTRACT Provided herein are novel azepinoindoles as 5-HT2C agonists, pharmaceutical compositions, use of such compounds in treating depression, drug...
by jlohrconsulting | Aug 20, 2025 | Uncategorized
ACS Med Chem Lett. 2025 Jul 30;16(8):1524-1525. doi: 10.1021/acsmedchemlett.5c00440. eCollection 2025 Aug 14. ABSTRACT Provided herein are novel non-hallucinogenic neurite growth compounds as 5-HT2A agonists, pharmaceutical compositions, use of such compounds in...
by jlohrconsulting | Aug 20, 2025 | Uncategorized
ACS Med Chem Lett. 2025 Jul 17;16(8):1503-1504. doi: 10.1021/acsmedchemlett.5c00415. eCollection 2025 Aug 14. ABSTRACT Provided herein are novel 3-(2-(aminoethyl)-indol-4-ol derivatives as 5-HT2C agonists, pharmaceutical compositions, use of such compounds in treating...
by jlohrconsulting | Aug 20, 2025 | Uncategorized
ACS Med Chem Lett. 2025 Jul 24;16(8):1437-1444. doi: 10.1021/acsmedchemlett.5c00287. eCollection 2025 Aug 14. ABSTRACT Melanostatin (MIF-1) is a naturally occurring neuropeptide acting as a positive allosteric modulator (PAM) of dopamine D2 receptors (D2R),...
by jlohrconsulting | Aug 20, 2025 | Uncategorized
Front Pharmacol. 2025 Aug 4;16:1621762. doi: 10.3389/fphar.2025.1621762. eCollection 2025. ABSTRACT INTRODUCTION: Depression is a widespread and debilitating disorder with a complex etiology involving oxidative stress, neuroinflammation, and apoptosis. Given the...
by jlohrconsulting | Aug 20, 2025 | Uncategorized
Lancet Reg Health Am. 2025 Aug 12;50:101207. doi: 10.1016/j.lana.2025.101207. eCollection 2025 Oct. ABSTRACT BACKGROUND: Despite elevated dementia risk, cognitive health among Indigenous older adults remains understudied. This study explored how modifiable factors...
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