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A phase 2 randomized, placebo-controlled study on the efficacy and safety of AR1001, a phosphodiesterase-5 inhibitor, in patients with mild-to-moderate Alzheimer’s disease

by jlohrconsulting | Sep 6, 2025 | Uncategorized

J Prev Alzheimers Dis. 2025 Sep 5:100337. doi: 10.1016/j.tjpad.2025.100337. Online ahead of print. ABSTRACT BACKGROUND: AR1001 is a phosphodiesterase-5 inhibitor that produces improved cognitive performance and reduces amyloid-β and phosphorylated tau burdens in...

Towards causal inference-based antidepressant selection with brain and blood biomarkers

by jlohrconsulting | Sep 6, 2025 | Uncategorized

Neuropsychopharmacology. 2025 Sep 5. doi: 10.1038/s41386-025-02183-3. Online ahead of print. ABSTRACT This report sought to employ multi-modal integration of pre-treatment brain (electroencephalogram, resting-state functional magnetic resonance imaging) and blood...

Estrogen receptor beta in lateral habenula mediates antidepressant effects of estrogen in postpartum-hormone-withdrawal-induced depression

by jlohrconsulting | Sep 6, 2025 | Uncategorized

Mol Psychiatry. 2025 Sep 5. doi: 10.1038/s41380-025-03215-6. Online ahead of print. ABSTRACT Dramatic drop in reproductive hormone, especially estrogen level, from pregnancy to postpartum period is known to contribute to postpartum depression (PPD), but the underlying...

Depression outcomes correlated to exposure to per- and poly-fluoroalkyl substances (PFAS)

by jlohrconsulting | Sep 6, 2025 | Uncategorized

Environ Sci Pollut Res Int. 2025 Sep 6. doi: 10.1007/s11356-025-36917-z. Online ahead of print. ABSTRACT Per- and poly-fluoroalkyl substances (PFAS) are fluorinated organic compounds known as forever chemicals that are used in many materials, from cooking appliances...

Differences in emotion regulation components underlie the sexual orientation disparity in depressive symptoms: a prospective, Population-based study of young adults

by jlohrconsulting | Sep 6, 2025 | Uncategorized

Soc Psychiatry Psychiatr Epidemiol. 2025 Sep 5. doi: 10.1007/s00127-025-02974-5. Online ahead of print. ABSTRACT PURPOSE: Hatzenbuehler’s psychological mediation framework proposes that difficulties in emotion regulation (ER), which are driven in part by excess...

Food insecurity and postnatal depression: the mediating effect of perceived social support among women in Khayelitsha, South Africa

by jlohrconsulting | Sep 6, 2025 | Uncategorized

Soc Psychiatry Psychiatr Epidemiol. 2025 Sep 5. doi: 10.1007/s00127-025-02986-1. Online ahead of print. ABSTRACT PURPOSE: Understanding the mechanisms through which poverty influences perinatal depression can provide insight into how to develop interventions to...
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Recent Posts

  • Dissociative Drug-Induced Anxiety
  • Associations in intentions to use anabolic-androgenic steroids among non-consuming boys and men with probable eating disorders and muscle dysmorphia
  • Assessing schema modes for eating disorders and their association with personality traits: validation of the English version of the short form of the schema modes inventory for eating disorders (EN-SMI-ED-SF)
  • Associations in intentions to use anabolic-androgenic steroids among non-consuming boys and men with probable eating disorders and muscle dysmorphia
  • Assessing schema modes for eating disorders and their association with personality traits: validation of the English version of the short form of the schema modes inventory for eating disorders (EN-SMI-ED-SF)

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