Prediction of Maternal and Fetal Exposure to Escitalopram, Sertraline, and Paroxetine by Combining Human Ex Vivo Placenta Perfusion Data and Physiologically Based Pharmacokinetic Modeling

Clin Pharmacokinet. 2025 Sep 27. doi: 10.1007/s40262-025-01574-5. Online ahead of print. ABSTRACT BACKGROUND: Depression is common in pregnant women, and selective serotonin reuptake inhibitors (SSRIs) are the most widely used antidepressants during pregnancy....