Esketamine versus fentanyl as adjuncts to hepatic hilar nerve block for ambulatory percutaneous liver tumor ablation focusing on respiratory safety: protocol for a randomized controlled trial

Front Pharmacol. 2025 Sep 17;16:1644029. doi: 10.3389/fphar.2025.1644029. eCollection 2025. ABSTRACT BACKGROUND: Opioid-induced respiratory depression (OIRD) is a critical safety concern during ambulatory percutaneous liver tumor thermal ablation. Esketamine has been...

Efficacy of auricular point-vagus nerve stimulation in adolescent insomnia patients and the brain function regulation mechanisms: a study protocol for an experimental, randomized, controlled clinical trial

Front Neurol. 2025 Sep 17;16:1643509. doi: 10.3389/fneur.2025.1643509. eCollection 2025. ABSTRACT BACKGROUND: Adolescent insomnia is a prevalent issue with significant implications for mental and physical well-being. Given the increasing incidence of sleep disorders,...