Determination of the 50% and 95% effective dose of esketamine combined with propofol for intravenous sedation in pediatric circumcision: study protocol for a randomized controlled, double-blind, dose-finding clinical trial

Trials. 2025 Oct 8;26(1):393. doi: 10.1186/s13063-025-09159-0. ABSTRACT BACKGROUND: Pediatric circumcision is a common yet often distressing procedure due to the associated pain and emotional response it can elicit in children. Adequate sedation and analgesia are...