Anxiety and depression in emerging adults: The STAND program as a model of scalable screening and intervention

Neuropsychopharmacology. 2025 Aug 29. doi: 10.1038/s41386-025-02174-4. Online ahead of print.

ABSTRACT

Depressive and anxiety disorders are highly and increasingly prevalent among 18 to 25 years olds as individuals emerge into adulthood. If untreated, these conditions have potentially serious consequences for social, academic and occupational functioning and confer risk for various mental health and health conditions, rendering prevention and treatment of paramount importance. After reviewing the evidence for prevalence, chronicity and cost of anxiety and depression in this transitional developmental period, we present evidence for psychotherapeutic and pharmacological interventions that can effectively prevent and treat depression and anxiety. Next, we describe the major barriers to prevention and treatment in young adults that result in significant unmet need. To address this mental health gap, we describe a digitally-supported, stratified stepped care system designed to overcome barriers while also personalizing the prevention and treatment of anxiety and depression, called Screening and Treatment for Anxiety and Depression (STAND). We conclude with challenges in this field of research and future.

PMID:40883543 | DOI:10.1038/s41386-025-02174-4