Antidepressant Discontinuation Syndrome
Resources for Patients and Caregivers
Typical symptoms of antidepressant discontinuation syndrome include flu-like symptoms, insomnia, nausea, imbalance, sensory disturbances, and hyperarousal. These symptoms usually are mild, last one to two weeks, and are rapidly extinguished with reinstitution of antidepressant medication.
Cluster Number:
Wiki Number: 06-Antidepressant Discontinuation Syndrome
Diagnosis: After a month of antidepressants sudden stops or even tapering off take a week to a year.
US Patients:
World Patients:
Sex Ratio:
Age Onset:
Brain Area: Antidepressants apparently reorganize the neurotransmitters, serotonin, dopamine, etc.
Symptoms: Flu-like, disturbed sleep and/or balance, nausea or sensory changes.
Progression: Occurs in 20-50% of stopping use of antidepressants, especially when stopped immediately.
Causes:
Medications:
Therapies:
Resources for Physicians, Counselors and Researchers
4 CURRENT ARTICLES
FROM PUBMED
The world-wide medical research
reports chosen for each diagnosis
Clicking each title opens the
PubMed article’s summary-abstract.
- Efficacy and safety of aripiprazole once-monthly versus oral aripiprazole in Chinese patients with acute schizophrenia: a multicenter, randomized, double-blind, non-inferiority studyby Le Xiao on January 6, 2022
CONCLUSIONS: This study confirmed the efficacy and safety of AOM for the treatment of Chinese patients with acute schizophrenia. The non-inferiority of AOM to oral aripiprazole was established, with comparable efficacy and tolerability. These findings suggested that AOM could be used as a treatment option for patients experiencing an acute episode of schizophrenia.
- Discontinuing antidepressants: Pearls and pitfallsby Samantha J Zwiebel on January 5, 2022
Stopping antidepressants can be challenging due to the high rate of discontinuation symptoms. Patients with antidepressant discontinuation syndrome (ADS) commonly experience insomnia, flu-like symptoms, mood disturbances, dizziness, and paresthesias, but a broad array of adverse effects is possible. Symptoms can last for days to months, and different symptoms have different durations. Patient education, identification of patients most at risk for developing symptoms, and a slow antidepressant...
- Importance of the individualized care process in a patient with recurrent acute coronary syndrome, multiple comorbidities and depressive syndromeby Antonella Spinelli on January 5, 2022
Statins have pleiotropic effects, including anti-inflammatory action, which is class-specific and contributes to a reduction in cardiovascular events. Statins also have a potential antidepressant effect. We report the case of a patient with depressive disorder and very high cardiovascular risk, in whom idiopathic myelofibrosis was also diagnosed. Due to the potential interaction of the antitumor drug (ruxolitinib) with atorvastatin and sertraline at the level of cytochrome P450, the latter two...
- Stopping antidepressants: withdrawal symptoms and rebound effects : Review and practical recommendationsby T Bschor on January 3, 2022
Stopping antidepressants can cause withdrawal (discontinuation) symptoms, the return of the original illness, and rebound. The latter means that the disease will return stronger, faster, or with greater likelihood than if it had not been treated with medication. The Psychiatry Working Group of the Drug Commission of the German Medical Association (AkdÄ) presents the scientific findings and provides practical recommendations for action. Withdrawal symptoms are multiform; unspecific physical...