Analysis of the correlation between mental status and ocular and systemic indicators in patients with primary angle-closure glaucoma

BMC Ophthalmol. 2025 Jul 7;25(1):393. doi: 10.1186/s12886-025-04227-0.

ABSTRACT

BACKGROUND: To analyze the poor mental status of patients with primary closed-angle glaucoma(PACG), and to explore the correlation between mental status and ocular and systemic indices in patients with PACG.

METHODS: We collected patients’ axial length (AL), anterior chamber depth (ACD), nerve fiber layer thickness (RNFL), cup-to-disc ratio (C/D), antinuclear antibody (ANA), toxoplasmosis antibody (anti-Toxoplasma gondii IgM), and anxiety and depression scores (HAMA and HAMD scales). Statistical analysis was utilized to analyze the data for each of the patients in the PACG and cataract patient groups.

RESULTS: The results showed that there was a statistically significant difference between the glaucoma group and the cataract group in terms of anxiety and depression scores, AL, ACD, RNFL, C/D, ANA, and Anti-Toxo IgM (P < 0.05). Anxiety scores of glaucoma patients were positively correlated with AL and C/D (P < 0.05), negatively correlated with RNFL (P < 0.05), and correlation existed with ANA and Anti-Toxo IgM (Eta² > 0.16). Depression scores in glaucoma patients were positively correlated with C/D (P < 0.05), negatively correlated with AL and RNFL (P < 0.05), and correlated with ANA and Anti-Toxo IgM (Eta² > 0.16). In addition,RNFL and C/D can be considered significant predictors of anxiety status. AL and C/D can be considered significant predictors of depression status.

CONCLUSION: Patients with primary angle-closure glaucoma have higher anxiety and depression scores than the general population, and clinically we can predict the patient’s mental status by their ocular and systemic indicators so that appropriate treatment can be taken in time.

PMID:40624620 | DOI:10.1186/s12886-025-04227-0