A progressive disease that destroys memory and other important mental functions.
Brain cell connections and the cells themselves degenerate and die, eventually destroying memory and other important mental functions.
Memory loss and confusion are the main symptoms.
No cure exists, but medications and management strategies may temporarily improve symptoms.
Wiki Number: W007
Diagnosis: Alzheimer’s Disease
World Patients: 30Mil
Sex Ratio: M; 3F
Age Onset: 65+to42% by 80+
Brain Area: hippocampus, amyloids & tau proteins, 19 genes
Symptoms: forgetting, poor short term memory, location confusion
Progression: poor thinking, repetitious conversations, abusive, anxious, paranoid, loses ability to live
Causes: 19 genes, head injuries, depression, hypertension, smoking
Medications: memantine, acetylcholinemesterase inhibitors
Therapies: Chess, book-reading, exercise;low-fat diet, caffeine, wine
4 CURRENT ARTICLES
The world-wide medical research
reports chosen for each diagnosis
Clicking each title opens the
PubMed article’s summary-abstract.
- Herpes Zoster Vaccination Reduces Risk of Dementiaby Steven Lehrer on October 26, 2021
CONCLUSION: Our finding that HZ vaccination reduces the risk of dementia is consistent with the link between viruses and AD. Herpes viruses-induced reactivation of embryologic pathways silenced at birth could be one of the pathologic processes in Alzheimer's disease.
- Self-reported cataract surgery and 10-year all-cause and cause-specific mortality: findings from the National Health and Nutrition Examination Surveyby Yifan Chen on October 26, 2021
CONCLUSIONS: This study found significant associations of self-reported cataract surgery with all-cause and vascular mortalities. Our findings provide potential insights into the pathogenic pathways underlying cataract.
- Analysis of Shared Genetic Regulatory Networks for Alzheimer's Disease and Epilepsyby Xiao-Dan Wang on October 26, 2021
Alzheimer's disease (AD) and epilepsy are neurological disorders that affect a large cohort of people worldwide. Although both of the two diseases could be influenced by genetic factors, the shared genetic mechanism underlying the pathogenesis of them is still unclear. In this study, we aimed to identify the shared genetic networks and corresponding hub genes for AD and epilepsy. Firstly, the gene coexpression modules (GCMs) were constructed by weighted gene coexpression network analysis...
- Loss of TDP-43 function underlies hippocampal and cortical synaptic deficits in TDP-43 proteinopathiesby Jiangxia Ni on October 26, 2021
TDP-43 proteinopathy is linked to neurodegenerative diseases that feature synaptic loss in the cortex and hippocampus, although it remains unclear how TDP-43 regulates mature synapses. We report that, in adult mouse hippocampus, TDP-43 knockdown, but not overexpression, induces robust structural and functional damage to excitatory synapses, supporting a role for TDP-43 in maintaining mature synapses. Dendritic spine loss induced by TDP-43 knockdown is rescued by wild-type TDP-43, but not...