The quantification of neurofilament light polypeptide (NFL) in biofluids is being clinically used to detect and grade general neuronal damage in neurodegenerative diseases and quantify neuronal injury during acute events like traumatic brain injury. Specific assays that target only particular molecular breakdown products of neurofilaments have the potential to distinguish between various pathologies. Nevertheless, the molecular structure of neurofilament light polypeptide in cerebrospinal fluid...

INTRODUCTION: Disruptions in estrogen exposure (i.e., surgically induced menopause) have been linked to poorer cognitive aging and dementia risk. Hormone therapy use (e.g., birth control, menopausal hormone therapy) has shown mixed associations with cognitive performance, possibly due to limited cognitive test batteries. To address previous inconsistencies, we investigated baseline data from Investigating Gains in Neurocognition in an Intervention Trial of Exercise (IGNITE). We hypothesized that...

The consumption and utilization of Ginkgo biloba leaves and seeds in traditional herbal treatments have left an indelible mark. Their rich chemical makeup and remarkable pharmacological effects, particularly in the form of EGb761 leaf extracts, have captivated researchers seeking novel treatments for degenerative nerve illnesses like Alzheimer's disease. However, the story of Ginkgo biloba doesn't end there. The Ginkgo biloba seeds, which were once highly regarded as sustenance and medicine but...

CONCLUSIONS: The efficacy of rTMS in memory function may promote the reversion of MCI to normal cognition, with the functional connectivity of DMN, ECN, and FPN playing a crucial important role. The severity of cognitive impairment and functional connectivity damage correlated with the likelihood of the reversion of MCI to normal cognition, underscoring the importance of early rTMS intervention for dementia prevention.