Alzheimer’s Disease
A progressive disease that destroys memory and other important mental functions.
Brain cell connections and the cells themselves degenerate and die, eventually destroying memory and other important mental functions.
Memory loss and confusion are the main symptoms.
No cure exists, but medications and management strategies may temporarily improve symptoms.
Cluster Number:
Wiki Number: W007
Diagnosis: Alzheimer’s Disease
US Patients:
World Patients: 30Mil
Sex Ratio: M; 3F
Age Onset: 65+to42% by 80+
Brain Area: hippocampus, amyloids & tau proteins, 19 genes
Symptoms: forgetting, poor short term memory, location confusion
Progression: poor thinking, repetitious conversations, abusive, anxious, paranoid, loses ability to live
Causes: 19 genes, head injuries, depression, hypertension, smoking
Medications: memantine, acetylcholinemesterase inhibitors
Therapies: Chess, book-reading, exercise;low-fat diet, caffeine, wine
Youtube Video: Alzheimer’s Disease-Early Signs
Amazon or Library Book:
Is It Alzheimer’s?
Amazon or Library Book:
36-Hour Day
Click the book to link or order from Amazon.
Click the book to link or order from Amazon.
Support Group: Alzheimer’s Association 800-272-3900
Contact your local Social Security office for possible Disability Benefits through their Disability Determination Services,
Section 12.02.
4 CURRENT ARTICLES
FROM PUBMED
The world-wide medical research
reports chosen for each diagnosis
Clicking each title opens the
PubMed article’s summary-abstract.
- High-dimensional mediation analysis reveals the mediating role of physical activity patterns in genetic pathways leading to AD-like brain atrophyby Hanxiang Xu on March 25, 2025
CONCLUSION: Through integrative analysis of multi-omics data, we identified several mediation pathways of physical activity between genetic factors and SPARE-AD. These findings contribute to a better understanding of the pathogenic mechanisms of AD. Moreover, our research demonstrates the potential of the high-dimensional mediation analysis method in revealing the mechanisms of disease.
- Caregiver burden of Alzheimer's disease among informal caregivers: a cross-sectional study in Malaysiaby Lyn Xuan Tay on March 25, 2025
Alzheimer's disease (AD) not only impacts the patients but substantially informal caregivers in terms of physical and psychological burden. This study aims to determine the burden level of informal caregivers of patients with different stages of AD and use of special accommodation (SpA) along with its predictors. A cross-sectional study was conducted by interviewing AD patients and informal caregivers recruited from 4 tertiary hospitals. Zarit Burden Interview (ZBI) was used to estimate...
- Multianalyte Nanopore Detection of Alzheimer's Biomarkers: A Label-Free Platform with Improved Sensitivity and Rangeby Qianshan Liu on March 25, 2025
Due to matrix interference, detection methods for protein biomarkers in body fluids are limited. Commonly used methods often require antibody modification or fluorescent labeling. Furthermore, subtle differences in protein sequences make it more challenging to detect and differentiate multiple biomarkers. This study introduces a novel nanopore-based method for simultaneous, label-free detection of key Alzheimer's disease (AD) biomarkers in biological samples. The technique enables...
- Retrotransposon: an insight into neurological disorders from perspectives of neurodevelopment and agingby Wenchuan Zhang on March 25, 2025
Neurological disorders present considerable challenges in diagnosis and treatment due to their complex and diverse etiology. Retrotransposons are a type of mobile genetic element that are increasingly revealed to play a role in these diseases. This review provides a detailed overview of recent developments in the study of retrotransposons in neurodevelopment, neuroaging, and neurological diseases. Retrotransposons, including long interspersed nuclear elements-1, Alu, SINE-VNTR-Alu, and...