Tourette Syndrome
A nervous system disorder involving repetitive movements or unwanted sounds.
Tourette syndrome starts in childhood.
It involves uncontrollable repetitive movements or unwanted sounds (tics), such as repeatedly blinking the eyes, shrugging shoulders, or blurting out offensive words.
Treatment may include medication or psychological therapies.
Cluster Number:
Wiki Number: PW217
Diagnosis: Tourette Syndrome
US Patients: 1% of school children and adolescents
World Patients:
Sex Ratio:
Age Onset: Ages 5-7; increases to ages 8-12; then decreases for 2/3 dramatically, can have adult onset or adult recurrence from childhood
Brain Area: dysfunction in neural circuits around the basal ganglia, combines genetic and environmental factors; poor brain circuit connections
Symptoms: Motor tics and vocal tics with blinking, coughing, throat-clearing, sniffing, facial movements. Nearby muscles “urge” first for 90%
Progression: corprolalia (obscene, inappropriate or derogatory remarks) occurs in 10%,; obscene gestures may be “muscular tics” for a few
Causes: Heritable 10X-100X;forceps delivery, paternal age, pregnancy stress, tobacco, caffeine, alcohol or pot during pregnancy, premature
Medications: None
Therapies:
Youtube Video: How Tourette’s Syndrome Impacts My Life
Amazon or Library Book: Coping with Tourette Syndrome
Click the book to link or order from Amazon.
Support Group: tourette.org; 888-486-8738 (Tourette Association)
4 CURRENT ARTICLES
FROM PUBMED
The world-wide medical research
reports chosen for each diagnosis
Clicking each title opens the
PubMed article’s summary-abstract.
- Genome-wide association study identifies 30 obsessive-compulsive disorder associated lociby Nora I Strom on May 7, 2024
Obsessive-compulsive disorder (OCD) affects ∼1% of the population and exhibits a high SNP-heritability, yet previous genome-wide association studies (GWAS) have provided limited information on the genetic etiology and underlying biological mechanisms of the disorder. We conducted a GWAS meta-analysis combining 53,660 OCD cases and 2,044,417 controls from 28 European-ancestry cohorts revealing 30 independent genome-wide significant SNPs and a SNP-based heritability of 6.7%. Separate GWAS for...
- Gilles de la Tourette syndrome as a rare co-morbidity of Klinefelter syndromeby Andrea E Cavanna on May 7, 2024
BACKGROUND: Klinefelter syndrome (47, XXY) is the most common sex chromosome aneuploidy. In addition to male hypergonadotropic hypogonadism, a wide range of neurodevelopmental disorders, anxiety and affective symptoms have been reported in a substantial proportion of cases.
- Network Pharmacology Combined with Animal Models to Investigate the Mechanism of ChangPu YuJin Tang in the Treatment of Tourette Syndromeby Man-Qi Lu on May 6, 2024
CONCLUSION: It was found that CPYJT protected neuronal cells from structural damage in multiple brain regions and affected the expression levels of BDNF, TrkB, PI3K, and Akt in the cortex, striatum, and thalamus during TS treatment.
- Internet-Delivered Exposure and Response Prevention for Pediatric Tourette Syndrome: 12-Month Follow-Up of a Randomized Clinical Trialby Per Andrén on May 3, 2024
CONCLUSIONS AND RELEVANCE: There were no statistically significant changes in tic severity from the 3-month through to the 12-month follow-up in either group. The ERP intervention was not superior to psychoeducation at any time point. While ERP was not superior to psychoeducation alone in reducing tic severity at the end of the follow-up period, ERP is recommended for clinical implementation due to its likely cost-effectiveness and support from previous literature.