A nervous system disorder involving repetitive movements or unwanted sounds.
Tourette syndrome starts in childhood.
It involves uncontrollable repetitive movements or unwanted sounds (tics), such as repeatedly blinking the eyes, shrugging shoulders, or blurting out offensive words.
Treatment may include medication or psychological therapies.
Wiki Number: PW217
Diagnosis: Tourette Syndrome
US Patients: 1% of school children and adolescents
Age Onset: Ages 5-7; increases to ages 8-12; then decreases for 2/3 dramatically, can have adult onset or adult recurrence from childhood
Brain Area: dysfunction in neural circuits around the basal ganglia, combines genetic and environmental factors; poor brain circuit connections
Symptoms: Motor tics and vocal tics with blinking, coughing, throat-clearing, sniffing, facial movements. Nearby muscles “urge” first for 90%
Progression: corprolalia (obscene, inappropriate or derogatory remarks) occurs in 10%,; obscene gestures may be “muscular tics” for a few
Causes: Heritable 10X-100X;forceps delivery, paternal age, pregnancy stress, tobacco, caffeine, alcohol or pot during pregnancy, premature
4 CURRENT ARTICLES
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- Boosted dopamine and blunted serotonin in Tourette syndrome - evidence from in vivo imaging studiesby Susanne Nikolaus on May 16, 2022
The precise cortical and subcortical mechanisms of Tourette syndrome (TS) are still not fully understood. In the present retrospective analysis, adolescent and adult medication-naïve patients showed increased DA transporter (DAT) binding in nucleus caudate (CAUD), putamen (PUT) and/or whole neostriatum (NSTR). D(2) receptor (R) binding and DA release were not different from controls throughout the nigrostriatal and mesolimbocortical system. When patients were medication-free (either...
- Classification of tic disorders based on functional MRI by machine learning: a study protocolby Fang Wang on May 16, 2022
INTRODUCTION: Tic disorder (TD) is a common neurodevelopmental disorder in children, and it can be categorised into three subtypes: provisional tic disorder (PTD), chronic motor or vocal TD (CMT or CVT), and Tourette syndrome (TS). An early diagnostic classification among these subtypes is not possible based on a new-onset tic symptom. Machine learning tools have been widely used for early diagnostic classification based on functional MRI (fMRI). However, few machine learning models have been...
- Dystonic motor and phonic tics in Tourette syndromeby José Fidel Baizabal-Carvallo on May 14, 2022
CONCLUSION: Dystonic tics, observed in about a third of patients with TS, are associated with increased severity of TS.
- Detection of Parent-of-Origin Effects for the Variants Associated With Behavioral Disinhibition in the MCTFR Databy Yi-Fan Kong on May 13, 2022
Behavioral disinhibition is one of the important characteristics of many mental diseases. It has been reported in literature that serious behavioral disinhibition will affect people's health and greatly reduce people's quality of life. Meanwhile, behavioral disinhibition can easily lead to illegal drug abuse and violent crimes, etc., which will bring great harm to the society. At present, large-scale genome-wide association analysis has identified many loci associated with behavioral...