Substance-Related Disorder

A chronic disease characterized by uncontrolled drinking and preoccupation Excessive use of psychoactive drugs, such as alcohol, pain medications, or illegal drugs. It can lead to physical, social, or emotional harm.


Cluster Number:
Wiki Number: PW215
Diagnosis: Substance-Related Disorder
US Patients: 7% of adults; 5% for alcohol; 2% for other drugs; 72,000 deaths from drug overdoses in 2017; 88,000 alcohol&480,000 tobacco deaths
World Patients: 2017-271 million (5.5% of adults) have used illicit drugs and 35 million, have an use disorder; 585,000 drug-deaths
Sex Ratio: Alcohol-only disorder 237 million men and 46 million women; 3 million alcohol-related deaths.
Age Onset: Children have 2X substance use disorders if parents hae them vs. parents without them.
Brain Area:
Symptoms: persistent use despite harm and adverse consequences: alcohol, caffeine, pot, phencyclidine, hallucinogens, inhalants, opioids, etc
Progression: can be mild, moderate or severe damage
Medications: detox; FDA has 2 for alcohol and opioid use; none for the cocaine, methamphetamine or other substance use disorders


The world-wide medical research
reports chosen for each diagnosis 

Clicking each title opens the
PubMed article’s summary-abstract.

  • Navigating Opioid Agonist Therapy among Young People who use Illicit Opioids in Vancouver, Canada
    by Andreas Pilarinos on July 3, 2022

    CONCLUSIONS: Findings underscore the importance of working collaboratively with young people to develop treatment plans and timelines, and suggest that OAT engagement and retention among young people could be improved by expanding access to the full range of OAT; updating clinical guidelines to improve access to safer prescription alternatives to the increasingly poisonous, unregulated drug supply; addressing treatment gaps arising from missed doses and take-home dosing; and providing a clear...

  • Impact of COVID-19 among people who use drugs: A qualitative study with harm reduction workers and people who use drugs
    by Fiona N Conway on July 2, 2022

    CONCLUSIONS: Our study highlighted critical systemic failures that contributed to the rise in overdose deaths during the COVID-19 pandemic. Addressing these challenges through policy reform and improved funding models will ensure the sustainability of harm reduction services and increase access to substance use treatment among highly vulnerable people who use drugs.

  • A Comprehensive Review of Zavegepant as Abortive Treatment for Migraine
    by Nazir Noor on July 1, 2022

    Migraine headache is a widespread and complex neurobiological disorder that is characterized by unilateral headaches that are often accompanied by photophobia and phonophobia. Migraine is one of the leading chief complaints in the emergency department with negative impacts on quality of life and activities of daily living. The high number of emergency presentations also results in a significant economic burden. Its risk factors include family history, genetics, sex, race, socioeconomics, the...

  • Working With Survivors of Human Trafficking: Results From a Needs Assessment in a Midwestern State, 2019
    by Kathleen M Preble on July 1, 2022

    CONCLUSION: The results suggest the need for statewide responses, such as legal assistance networks, telemental health options, and enhanced training collaborations between interpersonal violence and anti-human trafficking service providers. The study findings are generalizable beyond the study site in 3 ways that can guide strategic action: (1) they provide a framework for state-level analysis and strategic planning that parallels the results; (2) they show that regional variation is possible...