Substance-Related Disorder
A chronic disease characterized by uncontrolled drinking and preoccupation Excessive use of psychoactive drugs, such as alcohol, pain medications, or illegal drugs. It can lead to physical, social, or emotional harm.
Cluster Number:
Wiki Number: PW215
Diagnosis: Substance-Related Disorder
US Patients: 7% of adults; 5% for alcohol; 2% for other drugs; 72,000 deaths from drug overdoses in 2017; 88,000 alcohol&480,000 tobacco deaths
World Patients: 2017-271 million (5.5% of adults) have used illicit drugs and 35 million, have an use disorder; 585,000 drug-deaths
Sex Ratio: Alcohol-only disorder 237 million men and 46 million women; 3 million alcohol-related deaths.
Age Onset: Children have 2X substance use disorders if parents hae them vs. parents without them.
Brain Area:
Symptoms: persistent use despite harm and adverse consequences: alcohol, caffeine, pot, phencyclidine, hallucinogens, inhalants, opioids, etc
Progression: can be mild, moderate or severe damage
Causes:
Medications: detox; FDA has 2 for alcohol and opioid use; none for the cocaine, methamphetamine or other substance use disorders
Therapies:
Youtube Video: Substance Use Disorders-Dopamine Pathway
Youtube Video:
Substance Abuse Disorders
Amazon or Library Book:
Stahl’s Illustrated Substance Use and Impulsive Disorders
Support Group: Samhsa.gov; 800-662-4357
(U.S. Government Helpline)
Contact your local Social Security office for possible Disability Benefits through their Disability Determination Services,
Section 12.02.
4 CURRENT ARTICLES
FROM PUBMED
The world-wide medical research
reports chosen for each diagnosis
Clicking each title opens the
PubMed article’s summary-abstract.
- Measuring social integration, treatment, and mortality after substance use treatment: methodological elaborations in a 20-year follow-up studyby Tove Sohlberg on January 22, 2025
OBJECTIVE: Alcohol and Other Drug (AOD) disorders cause substantial harm. Effective Substance Use Treatment (SUT) exists, but long-term outcomes remain inconclusive. This study used a 20-year prospective follow-up of 1248 service users entering SUT in Stockholm, Sweden, in 2000-2002 to elaborate on how different dimensions of long-term outcomes may be measured by register-based indicators. Baseline characteristics and attrition bias were explicated, and register-based outcomes were examined.
- Elafibranor: A promising therapeutic approach for liver fibrosis and gut barrier dysfunction in alcohol-associated liver diseaseby Chun-Han Cheng on January 22, 2025
This article discusses the recent study written by Koizumi et al. Alcohol-associated liver disease (ALD) is a major cause of liver-related morbidity and mortality, which is driven by complex mechanisms, including lipid accumulation, apoptosis, and inflammatory responses exacerbated by gut barrier dysfunction. The study explored the therapeutic potential of elafibranor, a dual peroxisome proliferator-activated receptor alpha/delta agonist. In clinical trials, elafibranor has shown promise for the...
- Eye reactions under the influence of drugs of abuse as measured by smartphones: a controlled clinical study in healthy volunteersby Kiki W K Kuijpers on January 22, 2025
CONCLUSION: The ocular response to oxycodone, lorazepam, lisdexamphetamine and cannabis, as measured under controlled light conditions using a smartphone-based assessment, demonstrated distinct and readily distinguishable patterns for each substance.
- Single-cell landscape of the intrahepatic ecosystem in alcohol-related liver diseaseby Xiaofang Zhao on January 21, 2025
Alcohol-related liver disease (ALD) is a common chronic liver disease caused by long-term excessive alcohol consumption and responsible for more than half of all liver-related deaths worldwide. The molecular mechanisms associated with ALD were not fully understood. In this study, we performed single-cell RNA sequencing on liver tissues obtained from ALD patients and healthy liver donors. We identified an ALB^(+)KRT7^(+) epithelial population that expressed both hepatocyte and biliary markers...