Creutzfeldt-Jakob disease (CJD) is a rare degenerative disorder seen in the 6-8th decade of life. It manifests as a rapidly progressing cognitive deterioration, the etiopathogenesis of which is neuronal accumulation of aberrant prion protein [scrapie-associated prion protein (PrPSC)], resulting in mortality within 1 year of diagnosis. Clinical features such as dementia, myoclonus, cerebellar, and extrapyramidal symptoms are observed in CJD, which may be confused with other degenerative...

Parkinsonism, commonly associated with Parkinson disease (PD), can also arise from other neurodegenerative disorders or non-neurodegenerative causes such as vascular parkinsonism (VP). This case highlights the acute onset of VP following a stroke, contributing to the understanding of VP's varied presentations and the challenges in its diagnosis. A 54-year-old male with a history of cerebrovascular disease presented with behavioral changes and reduced activity, initially raising the suspicion of...

CONCLUSION: The findings of the study could have practical implications for clinicians, aiding in the understanding of low emotional expression and unexplained behavior among individuals and assisting in addressing the underlying vulnerability to facilitate their overcoming of these challenges. Additionally, it is suggested that a comprehensive strategy be used that addresses stigma, cultural values, and social norms in addition to legal issues to address the problem.

CONCLUSIONS: Clinically, these results facilitate more accurate prognostication of motor speech symptoms in speakers with PPAOS, allowing for timely introduction of alternative means of communication. The results also support the differentiation between progressive AOS and dysarthria as distinct motor speech disorders that often co-occur in these individuals.