A sedative or tranquilliser is a substance that induces sedation by reducing irritability or excitement. They are CNS depressants and interact with brain activity causing its deceleration. Various kinds of sedatives can be distinguished, but the majority of them affect the neurotransmitter gamma-aminobutyric acid.
Wiki Number: PW199
Diagnosis: Sedative (Tranquilizer)
US Patients: Works by reducing irritability or excitement. It is a Central Nervous System depressant causing brain activities’ deceleration.
World Patients: Most affect the GABA “neurotransmitter gamma-aminobutyric acid, relaxes by increasing GaBA activity. At higher doses it slurs one’s
Sex Ratio: speech, makes walking staggering, forces poor judgment and slows reflexes. Benzodiazapines can be used as an hypnotic for sleep.
Age Onset: When overused or comined an overdose can cause unconsciousness or death.
Brain Area: (1)an anxiolytic affects anxiety; (2)tranquilizer can refer to anxiolytic or antipsychotic; (3)soporific/sleeping pill mean hypnotics.
Symptoms: The article lists the types of sedatives: barbiturates, benzodiazepines, nonbenzodiazepine hypnotics, orexin antagonists,
Progression: first generation antihistamines, general anesthetics, herbal sedatives, methaqualone and analogues, skeletal muscle relaxants,
Causes: opioids, antidepressants, antipsychotics, and other. 124 individual sedatives are listed to prepare for surgery or other procedures.
Medications: In 2011, about half of US hospital admissions were from overuse of sedatives. Use can worsen psychiatric conditions like dementia,
Therapies: can cause amnesia. Some are dropped in bar-drinks before robberies and for date-rape.
4 CURRENT ARTICLES
The world-wide medical research
reports chosen for each diagnosis
Clicking each title opens the
PubMed article’s summary-abstract.
- Disparities in Use/Misuse of Specific Illicit and Prescription Drugs among Sexual Minority Adults in a National Sampleby Megan S Schuler on January 24, 2022
Background: Compared to heterosexual adults, lesbian, gay, and bisexual (LGB) adults have higher rates of any illicit drug use and any prescription drug misuse, yet disparities regarding specific drugs remain poorly characterized. Methods: We examined disparities by sexual identity and sex for 8 illicit and prescription drugs using 2015-2019 National Survey on Drug Use and Health data. Outcomes included past-year use/misuse of cocaine/crack, hallucinogens, inhalants, methamphetamine, heroin,...
- Effect of continuous deep sedation on survival in the last days of life of cancer patients: A multicenter prospective cohort studyby Naosuke Yokomichi on January 24, 2022
CONCLUSIONS: Continuous deep sedation with careful dose adjustment was not associated with shorter survival in the last days of life in patients with advanced cancer.
- Effect of high intensity laser therapy in the treatment of acute atlantoaxial rotatory subluxation: A case reportby Sheng-Hui Tuan on January 24, 2022
CONCLUSIONS: The patient had no complaints after HILT in a case of acute AARS resulting from a mechanical factor. Due to its pain-relief and muscle-release characteristics, HILT indicates the probable benefit of relaxation of spastic muscles for patients with AARS.
- Opioids in COVID-19: Two Sides of a Coinby Camila Vantini Capasso Palamim on January 24, 2022
Introduction: The treatment of most severe COVID-19 patients included the large-scale use of sedatives and analgesics-possibly in higher doses than usual-which was reported in the literature. The use of drugs that decrease mortality is necessary and opioids are important agents in procedures such as orotracheal intubation. However, these drugs seem to have been overestimated in the COVID-19 pandemic. We performed a review of the PubMed-Medline database to evaluate the use of opioids during this...