A sedative or tranquilliser is a substance that induces sedation by reducing irritability or excitement. They are CNS depressants and interact with brain activity causing its deceleration. Various kinds of sedatives can be distinguished, but the majority of them affect the neurotransmitter gamma-aminobutyric acid.
Wiki Number: PW199
Diagnosis: Sedative (Tranquilizer)
US Patients: Works by reducing irritability or excitement. It is a Central Nervous System depressant causing brain activities’ deceleration.
World Patients: Most affect the GABA “neurotransmitter gamma-aminobutyric acid, relaxes by increasing GaBA activity. At higher doses it slurs one’s
Sex Ratio: speech, makes walking staggering, forces poor judgment and slows reflexes. Benzodiazapines can be used as an hypnotic for sleep.
Age Onset: When overused or comined an overdose can cause unconsciousness or death.
Brain Area: (1)an anxiolytic affects anxiety; (2)tranquilizer can refer to anxiolytic or antipsychotic; (3)soporific/sleeping pill mean hypnotics.
Symptoms: The article lists the types of sedatives: barbiturates, benzodiazepines, nonbenzodiazepine hypnotics, orexin antagonists,
Progression: first generation antihistamines, general anesthetics, herbal sedatives, methaqualone and analogues, skeletal muscle relaxants,
Causes: opioids, antidepressants, antipsychotics, and other. 124 individual sedatives are listed to prepare for surgery or other procedures.
Medications: In 2011, about half of US hospital admissions were from overuse of sedatives. Use can worsen psychiatric conditions like dementia,
Therapies: can cause amnesia. Some are dropped in bar-drinks before robberies and for date-rape.
4 CURRENT ARTICLES
The world-wide medical research
reports chosen for each diagnosis
Clicking each title opens the
PubMed article’s summary-abstract.
- An overview and update on the chemical composition and potential health benefits of Opuntia ficus-indica (L.) Millerby Eman Yasser Abbas on July 3, 2022
Opuntia ficus-indica (OFI), widely recognized as prickly pear, is native to Mexico and it is distributed in many areas of the world because of its socioeconomic, agronomic, and ecological benefits, besides its large amounts of functional, nutraceutical, and biological activities. Various parts of this plant including the fruit pulp and peel, cladode, and seeds are scientifically proven to have therapeutic potentials and are safe for human use. The contents of phytochemical compounds in each part...
- Perisciatic Nerve Dexmedetomidine Alleviates Spinal Oxidative Stress and Improves Peripheral Mitochondrial Dynamic Equilibrium in a Neuropathic Pain Mouse Model in an AMPK-Dependent Mannerby Yang Mu on June 30, 2022
Neuropathic pain (NPP) is a debilitating clinical condition that presently has few effective treatments. NPP is caused by uncontrolled central oxidative stress and inflammation. Preliminary studies indicate that dexmedetomidine (DEX), an agonist of the alpha-2 adrenergic receptor, is beneficial for treating NPP. In this paper, the effects of administering DEX around injured nerves in a chronic constriction injury- (CCI-) induced neuropathic pain mouse model are investigated. According to the...
- Painless Gastrointestinal Endoscopy Assisted with Computed Tomography Image Information Data Monitoring in Postoperative Neurocognitive Dysfunction in Patients with Combined Anesthesia of Propofol and Butorphanol Tartrate under Electronic Healthby Yueguang Wei on June 30, 2022
The aim of this study was to explore the value of computed tomography (CT) images based on electronic health (E-health) combined with painless gastrointestinal endoscopy (PGE) in the diagnosis of neurocognitive function in patients with combined anesthesia of propofol and butorphanol tartrate. 126 patients undergoing PGE were selected as the research objects, and all were performed with CT perfusion imaging before and after anesthesia to obtain the cerebral blood volume (CBV), cerebral blood...
- Differential impact of antenatal exposure to antiseizure medications on motor and mental development in infants of women with epilepsyby Sanjeev V Thomas on June 30, 2022
OBJECTIVE: We aimed to determine a possible association between motor and mental development in infants of women with epilepsy and antenatal exposure to antiseizure medication (ASM).