Wiki Number: PW195
US Patients: 1.1% of the population;Life expectancy decreased by 20 years; sedentary life leads to heart attacks;
World Patients: 20 million total cases; 16.7 Million-disabled due to schizophrenia, 75% unemployed; Violence-6X population; with alcohol-24X.
Sex Ratio: M+;F
Age Onset: M-early 20’s; F-late 20’s and post-menopausal in women. Psychosis (reality-unreality) often preceeds schizophrenia.
Brain Area: dopamine controls positive motivations; genes CRHR1 and CRHBP relate to suicidal behavior, several brain areas involved
Symptoms: Hallucinations, delusions, disorganized thinking, withdrawal, apathy, weak emotions, word salad; cognitively poorer generally
Progression: Usually non-violent; more likely to be victims,unless using alcohol or drugs.
Causes: 70-80% heritable; raised in city, older parents, drugs or pot used as teenager, several factors during pregnancy; childhood traumas
Medications: antipsychotics, hospitalization to stop harm to self or others, many create restlessness, muscle-jerking, weight gain
Therapies: exercise, CBTs, other talking therapies, along with medications, ½improve, some get well; the other half, life-time involvement.
4 CURRENT ARTICLES
The world-wide medical research
reports chosen for each diagnosis
Clicking each title opens the
PubMed article’s summary-abstract.
- Pharmacotherapy of schizophrenia: immunological aspects and potential role of immunotherapyby Prerna Chauhan on October 16, 2021
INTRODUCTION: Schizophrenia is a complex disorder owing to diversity in clinical phenotypes, overlapping symptoms and heterogeneous clinical presentation. Even after decades of research, the exact causative mechanisms of schizophrenia are not completely known. Recent evidence indicates the role of immune dysfunction in schizophrenia pathogenesis as observed from alteration in immune cells, increased activity of complement cascade and development of autoantibodies against neurotransmitter...
- Trace Amine-Associated Receptor 1 as a Target for the Development of New Antipsychotics: Current Status of Research and Future Directionsby Joshua T Kantrowitz on October 16, 2021
Schizophrenia is a mental illness associated with an array of symptoms that often result in disability. The primary treatments for schizophrenia are termed antipsychotics. Although antipsychotics modulate a number of different receptor types and subtypes, all currently regulatory agency-approved antipsychotics share in common direct or functional antagonism at the dopamine type 2 receptor (D(2)R). The majority of people with schizophrenia do not achieve full resolution of their symptoms with...
- Clinical outcomes of paliperidone long-acting injection in patients with schizophrenia: a 1-year retrospective cohort studyby Hsue-Wei Chan on October 16, 2021
CONCLUSIONS: PLAI reduces the incidence of admission and emergency room visits.
- Olfactory dysfunction and face processing of social cognition in first-episode psychosisby Semra Etyemez on October 16, 2021
Olfactory functional deficits have been reported in psychotic disorders. Olfactory dysfunction has a predictive value for prognosis and disease course. Thus, it is important to know which specific symptoms and cognitive changes are associated with olfactory dysfunction in early-stage psychosis. Deficits in social cognition are a difficult problem in psychosis. Here we conduct a detailed assessment of odor function and face processing and show that odor discrimination capacity is specifically...