CONCLUSIONS: The developed popPK model, together with corresponding simulations, supports TV-46000 as a LASCA that offers flexible dosing intervals (q1m or q2m) and administration sites (abdomen or upper arm) and does not require oral supplementation or loading dose(s).

Myanmar has experienced decades of military dictatorship, civil wars, religious violence, economic crises, and natural disasters. While these conditions would suggest very high rates of depression and anxiety, government statistics report an exceptionally low depression rate of 0.00006%, compared to the global rate of 3.4%. This study combines analysis of epidemiological data, ethnographic observation of clinics, and in-depth interviews. I argue that Myanmar's low depression rates cannot be...

Sleep supports memory consolidation, but the specific roles of different sleep stages in this process remain unclear. While rapid eye movement sleep (REM) has traditionally been linked to the processing of emotionally charged material, recent evidence suggests that slow wave sleep (SWS) also plays a role in strengthening emotional memories. Here, we use targeted memory reactivation (TMR) during REM and SWS in a daytime nap to directly examine which sleep stage is primarily involved in...

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