Schizoaffective Disorder

Schizoaffective disorder is a combination of symptoms of schizophrenia and mood disorder, such as depression or bipolar disorder. Symptoms may occur at the same time or at different times.
Cycles of severe symptoms are often followed by periods of improvement. Symptoms may include delusions, hallucinations, depressed episodes, and manic periods of high energy.
People with this disorder generally do best with a combination of medications and counseling.


Cluster Number:
Wiki Number: PW193
Diagnosis: Schizoaffective Disorder-Much of the Wikipedia article dealt with the validity of this particular diagnosis.
US Patients: 0.5-.0.8 (less than 1)% sometime in their lives
World Patients:
Sex Ratio: M;W+. More women in depressive; about even numbers in bipolar areas.
Age Onset: 30% between ages 25 and 35.
Brain Area: abnormal thoughts, unstable mood; psychotic symptoms for two weeks without any mood disorders. IT’s often misdiagnosed.
Symptoms: Bipolar has mania; hypomania and mixed episode vs. depressive only. May have hallucinations, delusions, disorganized speech and
Progression: thinking. May include audiotory hasllucinations.
Causes: Genetics under environmental stresses; age of the father at conception; pot and other substance abuses may be factors as well.
Medications: antipsychotics, mood stabilizers and antidepressants; electroconvulsive therapy for severe and resistant symptoms.
Therapies: Returning the patient to do the normal activities of life along with vocational rehabilitation.

Youtube Video:

Schizophrenia vs. Schizophreniform vs. Schizoid vs. Schizotypal

Amazon or Library Book: Schizoaffective Disorder

Click the book to link or order from Amazon.

 Contact your local Social Security office for possible Disability Benefits through their Disability Determination Services,

Section 12.03.


The world-wide medical research
reports chosen for each diagnosis 

Clicking each title opens the
PubMed article’s summary-abstract.

  • The host genetics affects gut microbiome diversity in Chinese depressed patients
    by Ke Han on January 26, 2023

    The gut microbiome and host genetics are both associated with major depressive disorder (MDD); however, the molecular mechanisms among the associations are poorly understood, especially in the Asian, Chinese group. Our study applied linear discriminant analysis (LDA) effect size (LEfSe) and genome-wide association analysis in the cohort with both gut sequencing data and genomics data. We reported the different gut microbiota characteristics between MDD and control groups in the Chinese group and...

  • Cariprazine - an Alternative Treatment for Clozapine-resistant Schizophrenia?
    by Adam Montgomery on January 26, 2023

    Treatment-resistant schizophrenia (TRS) poses a significant therapeutic challenge in psychiatric practice. Clozapine is recognized as a treatment of choice in TRS but is not always effective in alleviating patients' symptoms. Additionally, clozapine therapy is associated with multiple side effects and monitoring requirements that often limit its use and negatively affect patients' compliance with the treatment. Although clozapine augmentation options are available, there is currently no...

  • A decrease in NR2B expression mediated by DNA hypermethylation induces perioperative neurocognitive disorder in aged mice
    by Feifei Xu on January 25, 2023

    CONCLUSIONS: Laparotomy cause hippocampus-dependent cognitive decline by hypermethylating the NR2B gene, allowing us to understand the pathogenesis of PND in an epigenetic landscape.

  • Progressive Multifocal Leukoencephalopathy Associated With Idiopathic CD8+ Lymphocytopenia
    by Marta Lopes on January 25, 2023

    Progressive multifocal leukoencephalopathy (PML) is a severe demyelinating disease of the central nervous system (CNS) caused by the polyoma John Cunningham (JC) virus. This virus is rarely pathogenic in immunocompetent individuals, being associated with profound cellular immunosuppression. We present a case of a 72-year-old woman with schizoaffective disorder who presented to the emergency department with dysarthria and right hemiataxia. The initial computer tomography was normal and the...