Restless Legs Syndrome
Wiki Number: PW187
Diagnosis: Restless Legs Syndrome (
US Patients: 2-15% of the population, higher %s when along with some other difficulties.
Sex Ratio: M;F2
Age Onset: “Early Onset RLS” hereditary, starts before age 45 and worsens over time. Late-onset RLS starts suddenly after 45, doesn’t worsen’
Brain Area: genetic, autosomal dominant (only needs gene from one parent)
Symptoms: Long term-urging leg (and sometimes arm) movement; sensation/pain begins while awake but relaxing.
Progression: worsened by any surgery, but especially back surgery or injury
Causes: “motor restlessness” – worsen by relaxation, iron deficiency, dopamine changes, reduced leg-oxygen levels, some medications
Medications: gabapentin, opioids – when resistant to other medications
Therapies: regular exercise, good sleep practices, stopping smoking; stretching legs and walking bring temporary relief
4 CURRENT ARTICLES
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PubMed article’s summary-abstract.
- Brain-iron deficiency models of restless legs syndromeby ChristopherJ Earley on July 2, 2022
Restless legs syndrome (RLS) is a common sensorimotor disorder for which two main pathological elements are fairly well accepted: Brain iron deficiency (BID) and an altered dopaminergic system. The ability to better understand the causal and consequential factors related to these two pathological elements, would hopefully lead to the development of better therapeutic strategies for treating, if not curing, this disease. The current understanding of the relationship between these two elements is...
- The prevalence of poor sleep quality and its association with the risk of obstructive sleep apnea and restless legs syndrome in diabetic patients treated with cyanoacrylate glue for varicose veinsby Hüseyin Demirtaş on July 1, 2022
CONCLUSIONS: This prospective study showed that restless legs syndrome, a high level of HbA1c, and dressed injection area of the skin are associated with poor sleep quality in patients with diabetes having chronic venous insufficiency and varicose veins treated with cyanoacrylate glue. Additionally, participants had better sleep quality 1 month after the peripheral embolization compared to the fifth day after the operation.
- Identification of restless legs syndrome in polysomnography studies and its association with other variablesby V Aldinio on June 29, 2022
CONCLUSION: The prevalence of RLS in subjects studied with Polysomnography is high and it was associated with clinically significant fatigue, insomnia and depression. These symptoms should be identified in order to establish an adequate therapeutic strategy. The prevalence of periodic limb movements was low and was not linked with RLS. These findings contrast with previous publications. Therefore, it requires additional studies to clarify the cause of this variation.
- Primary dysmenorrhoea in adolescents and young women: A twin family study of maternal transmission, genetic influence and associationsby Phillip Aouad on June 27, 2022
CONCLUSION: Primary dysmenorrhea in adolescents and young women was shown to be relatively strongly genetically influenced and associated especially with a history of iron deficiency and painless RLS which have potential therapeutic implications.