Restless Legs Syndrome

A condition characterized by a nearly irresistible urge to move the legs, typically in the evenings.

Restless legs syndrome typically occurs while sitting or lying down. It generally worsens with age and can disrupt sleep.

The main symptom is a nearly irresistible urge to move the legs.

Getting up and moving around helps the unpleasant feeling temporarily go away. Self-care steps, lifestyle changes, or medications may help.

Cluster Number:
Wiki Number: PW187
Diagnosis: Restless Legs Syndrome (
US Patients: 2-15% of the population, higher %s when along with some other difficulties.
World Patients:
Sex Ratio: M;F2
Age Onset: “Early Onset RLS” hereditary, starts before age 45 and worsens over time. Late-onset RLS starts suddenly after 45, doesn’t worsen’
Brain Area: genetic, autosomal dominant (only needs gene from one parent)
Symptoms: Long term-urging leg (and sometimes arm) movement; sensation/pain begins while awake but relaxing.
Progression: worsened by any surgery, but especially back surgery or injury
Causes: “motor restlessness” – worsen by relaxation, iron deficiency, dopamine changes, reduced leg-oxygen levels, some medications
Medications: gabapentin, opioids – when resistant to other medications
Therapies: regular exercise, good sleep practices, stopping smoking; stretching legs and walking bring temporary relief

CLICK HERE FOR THE FULL WIKIPEDIA ARTICLE.

Youtube Video:

Restless Leg Syndrome

Youtube Video: Kids Not Sleeping-Restless Legs Might Be The Problem

Amazon or Library Book: Restless Legs Syndrome

Click the book to link or order from Amazon.

Support Group: rls.org; 512-366-9109 (Restless Legs Foundation)

4 CURRENT ARTICLES
FROM PUBMED

The world-wide medical research
reports chosen for each diagnosis

Clicking each title opens the
PubMed article’s summary-abstract.

Compromised Dynamic Cerebral Autoregulation in Patients with Restless Legs Syndrome
by Yanan Zhang on May 6, 2024
CONCLUSION: The dCA was compromised in moderate, severe, and very severe RLS patients and was negatively correlated with the IRLS, arousal index, and PLMI. After 1 month of therapy, dCA improved in RLS patients.
A Historical Overview of the Role of Benzodiazepines including Clonazepam in the Treatment of Adult Restless Legs Syndrome and Periodic Limb Movements in Sleep
by Arthur S Walters on May 6, 2024
In a recent survey of 16,694 people receiving treatment for Restless Legs Syndrome (RLS), approximately 25% were treated with benzodiazepines either singly or in combination with other RLS treatments. Because of the large number of people receiving benzodiazepines for treatment of RLS, we conducted a historical overview of the therapeutic role of benzodiazepines in RLS and its associated condition Periodic Limb Movements in Sleep (PLMS). We found 17 articles on the use of clonazepam in RLS,...
Prevalence of restless legs syndrome in adults with epilepsy: A systematic review and meta-analysis of observational studies
by Ahmed M Talaia on May 6, 2024
CONCLUSIONS: This meta-analysis provides the first pooled estimate of RLS prevalence in AWE. RLS occurs in 15 out of every 100 AWE patients, and the risk is high compared to healthy controls. However, the findings need to be confirmed in future studies owing to limitations in the analysis and study design.
Evaluation of the relationship between restless legs syndrome, mental status, and sleep disorders among Moroccan women during their third trimester of pregnancy
by Maroua Guerroumi on May 2, 2024
CONCLUSION: RLS is encountered during the prenatal period, with a higher prevalence in the last trimester. During this stage of pregnancy, women suffering from RLS were vulnerable to anxiety and sleep disorders. Prevention and early diagnosis of RLS could be a proactive healthcare management leading to better health outcomes and better conditions of pregnancy, which precedes childbirth.