Restless Legs Syndrome
Cluster Number:
Wiki Number: PW187
Diagnosis: Restless Legs Syndrome (
US Patients: 2-15% of the population, higher %s when along with some other difficulties.
World Patients:
Sex Ratio: M;F2
Age Onset: “Early Onset RLS” hereditary, starts before age 45 and worsens over time. Late-onset RLS starts suddenly after 45, doesn’t worsen’
Brain Area: genetic, autosomal dominant (only needs gene from one parent)
Symptoms: Long term-urging leg (and sometimes arm) movement; sensation/pain begins while awake but relaxing.
Progression: worsened by any surgery, but especially back surgery or injury
Causes: “motor restlessness” – worsen by relaxation, iron deficiency, dopamine changes, reduced leg-oxygen levels, some medications
Medications: gabapentin, opioids – when resistant to other medications
Therapies: regular exercise, good sleep practices, stopping smoking; stretching legs and walking bring temporary relief
4 CURRENT ARTICLES
FROM PUBMED
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PubMed article’s summary-abstract.
- Editorial: EEG and fMRI for Sleep and Sleep Disorders-Mechanisms and Clinical Implicationsby Xi-Jian Dai on October 15, 2021
No abstract
- Iron deficiency in pregnancy: Influence on sleep, behavior, and molecular markers of adult male offspringby Beatriz Franco on October 15, 2021
Iron restriction during pregnancy can lead to iron deficiency and changes in the dopaminergic system in the adulthood of offspring, and restless legs syndrome (RLS) is closely related to these changes. Objectives: Analyze whether iron restriction during pregnancy would cause changes in the behavior, sleep, and dopaminergic system of the male offspring. In addition, we aimed to assess whether exercise would be able to modulate these variables. The pregnant rats (Wistar) were divided into four...
- Restless legs syndrome in pediatric onset multiple sclerosisby Beyza Citci Yalcinkaya on October 8, 2021
CONCLUSION: Our study demonstrated high prevalence of RLS/WED in young patients with POMS. Higher EDSS scores in patients with POMS and RLS/WED indicates disease-related factors in the emergence of RLS/WED.
- Pharmacological and Nonpharmacological Treatments for Restless Legs Syndrome in End Stage Kidney Disease: A Systematic Review and Component Network Meta-Analysisby Jia-Jin Chen on October 6, 2021
CONCLUSIONS: The NMA supports that cool dialysate is appropriate to apply to treat patients with ESKD and RLS. Gabapentin is most effective pharmacologic intervention which also might improve sleep quality. Further parallel RCTs with sufficient sample sizes are required to evaluate these potential interventions and long-term effects.