Restless Legs Syndrome
Cluster Number:
Wiki Number: PW187
Diagnosis: Restless Legs Syndrome (
US Patients: 2-15% of the population, higher %s when along with some other difficulties.
World Patients:
Sex Ratio: M;F2
Age Onset: “Early Onset RLS” hereditary, starts before age 45 and worsens over time. Late-onset RLS starts suddenly after 45, doesn’t worsen’
Brain Area: genetic, autosomal dominant (only needs gene from one parent)
Symptoms: Long term-urging leg (and sometimes arm) movement; sensation/pain begins while awake but relaxing.
Progression: worsened by any surgery, but especially back surgery or injury
Causes: “motor restlessness” – worsen by relaxation, iron deficiency, dopamine changes, reduced leg-oxygen levels, some medications
Medications: gabapentin, opioids – when resistant to other medications
Therapies: regular exercise, good sleep practices, stopping smoking; stretching legs and walking bring temporary relief
Youtube Video:
Restless Leg Syndrome
Youtube Video: Kids Not Sleeping-Restless Legs Might Be The Problem
Amazon or Library Book: Restless Legs Syndrome
Click the book to link or order from Amazon.
Support Group: rls.org; 512-366-9109 (Restless Legs Foundation)
4 CURRENT ARTICLES
FROM PUBMED
The world-wide medical research
reports chosen for each diagnosis
Clicking each title opens the
PubMed article’s summary-abstract.
- Efficacy and safety of intravenous ferric carboxymaltose in the treatment of Restless Legs Syndrome: a systematic review and meta-analysisby Ayesha Khan on January 22, 2025
CONCLUSION: In conclusion, intravenous ferric carboxymaltose significantly reduces Restless Legs Syndrome symptoms, especially in patients with confirmed iron deficiency. The treatment appears generally well-tolerated, with adverse effects being manageable. However, further long-term studies are needed to fully assess the safety profile and confirm sustained symptom improvement in a broader population.
- Acupuncture treatment of restless legs syndrome: a randomized clinical controlled study protocol based on PET-CT and fMRIby Lin Tang on January 17, 2025
INTRODUCTION: Restless legs syndrome (RLS) is a sensorimotor disorder of the nervous system that is mainly characterized by nighttime leg discomfort and can be accompanied by significant anxiety, depression, and other mood disorders. RLS seriously affects the quality of life. Clinical studies have confirmed that acupuncture can alleviate the clinical symptoms of RLS. This randomized controlled trial (RCT) aims to investigate the efficacy of acupuncture in the treatment of RLS and further explore...
- Clinical impact of restless legs syndrome in patients with migraine: a 12-year, single-center, longitudinal studyby Keisuke Suzuki on January 13, 2025
Although many studies have indicated a significant association between migraine and restless legs syndrome (RLS), few long-term longitudinal studies have examined RLS in patients with migraine. We conducted a single-center, 12-year, longitudinal study of migraine patients and assessed whether RLS was present in 2010, 2017, or 2022 to evaluate its associations with clinical factors. Headache-related disability was assessed using the Migraine Disability Assessment (MIDAS). Sleep quality, daytime...
- The impact of uric acid levels in the pathophysiology and its contribution to the prediction of diagnosis in restless legs syndromeby Esma Kobak Tur on January 13, 2025
Restless legs syndrome (RLS) is characterized by an uncomfortable urge to move the legs, worsened in the evening, occurring at rest, and relieved temporarily by movement. Although its pathophysiology remains incompletely understood, oxidative stress has been suggested. Uric acid (UA) is a marker associated with oxidative stress, and its reduced levels pose a risk for certain neurodegenerative diseases. In this study, we aimed to assess serum UA concentrations in RLS patients to gain insights...